Vitamin K-Dependent Coagulation Factors Deficiency

被引：52
|
作者：
Brenner, Benjamin [1 ,2 ]
Kuperman, Amir A. [1 ,2 ]
Watzka, Matthias [3 ]
Oldenburg, Johannes [3 ]
机构：
[1] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
[2] Technion Israel Inst Technol, Thrombosis & Hemostasis Unit, Inst Hematol, Rambam Med Ctr, Haifa, Israel
[3] Univ Clin Bonn, Inst Expt Haematol & Transfus Med, Bonn, Germany
来源：
SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2009年 / 35卷 / 04期
关键词：
Vitamin K-dependent coagulation factors deficiency (VKCFD); gamma-glutamyl carboxylase (GGCX); vitamin K epoxide reductase (VKOR); GAMMA-GLUTAMYL-CARBOXYLASE; CONGENITAL COMBINED DEFICIENCY; WARFARIN-RESISTANCE; EPOXIDE-REDUCTASE; FACTOR-VII; FACTOR-II; FACTOR-IX; HEREDITARY-DEFICIENCY; BINDING-SITE; FACTOR-X;
D O I：
10.1055/s-0029-1225766
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
All vitamin K-dependent coagulation factors require normal function of gamma-glutamyl carboxylase and vitamin K epoxide reductase enzyme complex (VKORC1.). Heritable dysfunction of gamma-glutamyl carboxylase or of the VKORC1 complex results in the secretion of poorly carboxylated vitamin K-dependent proteins that play a role In coagulation. The following review will summarize the clinical manifestations of vitamin K-dependent coagulation factors deficiency I and II and will provide a detailed explanation about the gene and protein structure, the function of the protein, and an analysis of the previously reported mutations. Laboratory assays used for diagnosis will be discussed, and treatment for various clinical settings will be recommended.
引用
收藏
页码：439 / 446
页数：8
相关论文
共 50 条
  • [21] Suspected vitamin K-dependent coagulation factor deficiency in pregnancy: A case report
    Ayyash, Mariam
    Chitlur, Meera
    Oldenburg, Johannes
    Shaman, Majid
    CASE REPORTS IN WOMENS HEALTH, 2022, 34
  • [22] HEREDITARY ABNORMALITY OF VITAMIN K-DEPENDENT COAGULATION
    GOLDSMITH, GH
    PENCE, RE
    RATNOFF, OD
    ADELSTEIN, DA
    FURIE, B
    CLINICAL RESEARCH, 1981, 29 (02): : A570 - A570
  • [23] HEMOSTASIS DISORDERS CAUSED BY DEFICIENCY OF VITAMIN K-DEPENDENT COAGULATION FACTORS: PATHOGENESIS, CORRECTION METHODS AND RECOMMENDATIONS FOR TREATMENT
    Galstyan, G. M.
    GEMATOLOGIYA I TRANSFUZIOLOGIYA, 2012, 57 (02): : 7 - 21
  • [24] RELEASE OF VITAMIN K-DEPENDENT COAGULATION FACTORS BY ISOLATED PERFUSED RAT LIVER
    KAZMIER, FJ
    SPITTELL, JA
    BOWIE, EJW
    THOMPSON, JH
    OWEN, CA
    AMERICAN JOURNAL OF PHYSIOLOGY, 1968, 214 (04): : 919 - &
  • [25] Effect of Ca2+ on the structure of vitamin K-dependent coagulation factors
    Sunnerhagen, M
    Drakenberg, T
    Forsen, S
    Stenflo, J
    HAEMOSTASIS, 1996, 26 : 45 - 53
  • [26] HEREDITARY COMBINED VITAMIN K-DEPENDENT COAGULATION FACTOR DEFICIENCY: REPORT OF A NEW CASE
    Angeles Dasi, M.
    Izquierdo, S.
    Moscardo, A.
    Vila, V.
    Argiles, B.
    Teresa Santos, M.
    Valles, J.
    THROMBOSIS RESEARCH, 2014, 133 : S92 - S92
  • [27] DEFICIENCY OF VITAMIN-K-DEPENDENT COAGULATION-FACTORS
    KLASNER, A
    LONGEE, D
    STINE, K
    BECTON, D
    CLINICAL RESEARCH, 1993, 41 (04): : A803 - A803
  • [28] Inherited deficiency of multiple vitamin K-dependent coagulation factors and coagulation inhibitors presenting as hemorrhagic diathesis, mental retardation, and growth retardation
    Ghosh, K
    Shetty, S
    Mohanty, D
    AMERICAN JOURNAL OF HEMATOLOGY, 1996, 52 (01) : 67 - 67
  • [29] Relationship between Acquired Deficiency of Vitamin K-dependent Clotting Factors And Hemorrhage
    Yang, Rui
    Zhang, Xiaoping
    Wei, Wenning
    Hong, Mei
    Yang, Yan
    Hu, Yu
    JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES, 2010, 30 (03) : 312 - 317
  • [30] Congenital combined deficiency of vitamin K-dependent coagulation factors (II, VII, IX, X) and proteins C and S
    Pedeferri, M
    Carrera, A
    Cogliardi, A
    Crippa, R
    Isimbaldi, C
    RIVISTA ITALIANA DI PEDIATRIA-ITALIAN JOURNAL OF PEDIATRICS, 1996, 22 (02): : 182 - 189
12345