Optimizing long-term response to methadone maintenance treatment: A 152-week follow-up using higher-dose methadone

被引:58
作者
Maxwell, S [1 ]
Shinderman, MS [1 ]
机构
[1] Ctr Addict Problems, Chicago, IL 60610 USA
关键词
methadone; high dose methadone; methadone maintenance;
D O I
10.1300/J069v21n03_01
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
We report the clinical course over 152 weeks of 245 patients in methadone maintenance treatment: 144 high dose (HD) patients (greater than or equal to100 mg/d, mean 211 mg/d), and 101 control (C) patients (<100 mg/d, mean 65 mg/d). After 152 weeks the mean methadone doses were 284.9 mg/d (range 13-1100 mg/d) and 94.0 mg/d (range 10-500 mg/d), respectively. Overall retention in treatment was 59% over the 152 weeks, with the HD group having significantly better retention (61.1% vs. 46.3%) and lower rates of positive urine toxicologies (16.0% vs. 36.6%). Mortality was statistically the same for the HD group (2/144, 1.4%) and the C group (2/101, 1.9%) over the 152-week period. We conclude that doses of methadone exceeding 100 mg/d are safe and effective in long-term maintenance treatment. We attribute the favorable outcomes we report to a model of treatment that emphasizes medication management in the treatment of opioid addiction.
引用
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页码:1 / 12
页数:12
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