Altered nociceptive response in ADAM11-deficient mice

被引：19
作者：
Takahashi, Eiki [1 ]
Sagane, Koji [1 ]
Nagasu, Takeshi [1 ]
Kuromitsu, Junro [1 ]
机构：
[1] Eisai & Co Ltd, Tsukuba Res Lab, Tsukuba, Ibaraki 3002635, Japan
来源：
BRAIN RESEARCH | 2006年 / 1097卷
关键词：
ADAM11; ADAM11-deficient mice; nociceptive transmission; Von Frey test; hot plate test; formalin paw test; acetic acid writhing test;
D O I：
10.1016/j.brainres.2006.04.043
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test. Our results indicate that the cell adhesion-related molecule ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：39 / 42
页数：4
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