The role of decidual NK cells in pregnancies with impaired vascular remodelling

被引：28
作者：
Cartwright, Judith E. [1 ]
James-Allan, Laura [1 ]
Buckley, Rebecca J. [1 ]
Wallace, Alison E. [1 ]
机构：
[1] St Georges Univ London, Cardiovasc & Cell Sci Inst, Reprod & Cardiovasc Dis Res Grp, Cranmer Terrace, London SW17 0RE, England
来源：
JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2017年 / 119卷
关键词：
Natural killer cell; Decidua; Trophoblast; Spiral artery; Pregnancy; Pre-eclamspia; NATURAL-KILLER-CELLS; IMMUNOGLOBULIN-LIKE RECEPTORS; UTERINE ARTERY RESISTANCE; FETAL-MATERNAL INTERFACE; 1ST-TRIMESTER PREGNANCIES; EXTRAVILLOUS TROPHOBLASTS; INCREASED APOPTOSIS; PERIPHERAL-BLOOD; GENE-EXPRESSION; HIGHER RISK;
D O I：
10.1016/j.jri.2016.09.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The pathologies of the dangerous pregnancy complications pre-eclampsia (PE) and fetal growth restriction (FGR) are established in the first trimester of human pregnancy yet we know little of how this happens. Finely tuned interactions between maternal and placental cells are essential for pregnancy to progress without complications; however, the precise nature of this cross-talk and how it can go wrong are crucial questions that remain to be answered. This review summarises recent studies examining the role played by natural killer cells in regulating normal placentation and remodelling. Their involvement when it is impaired in PE/FGR pregnancies will additionally be discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：81 / 84
页数：4
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