Spiroquinazoline support studies: methods for the preparation of imidazoloindolines from oxindoles

被引：18

作者：

Barbosa, Yomadis A. Ortiz ^{[1
]}

Hart, David J. ^{[1
]}

Magomedov, Nabi A. ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 37期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tet.2006.06.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two methods for the annulation of glycine to the I and 2 positions of oxindoles are described. The first method involves introduction of an alpha-azidoacetyl group on the oxindole nitrogen followed by an intramolecular Staudinger reaction to complete the annulation. The second method involves acylation of the oxindole nitrogen with an N-Cbz-glycine derivative followed by reduction of the oxindole carbonyl group and subsequent cyclization to provide an imidazoloindoline. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：8748 / 8754

页数：7

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