Animal venoms/toxins and the complement system

被引：31

作者：

Tambourgi, Denise V. ^{[1
]}

van den Berg, Carmen W. ^{[2
]}

机构：

[1] Butantan Inst, Immunochem Lab, Sao Paulo, Brazil

[2] Cardiff Univ, Sch Med, Inst Mol & Expt Med, Cardiff CF10 3AX, S Glam, Wales

来源：

MOLECULAR IMMUNOLOGY | 2014年 / 61卷 / 02期

关键词：

Animal venoms; Complement system; Toxins; COBRA VENOM FACTOR; LOXOSCELES SPIDER VENOM; BROWN RECLUSE SPIDER; PROTEOLYTIC-ENZYME INHIBITOR; SERRULATUS SCORPION-VENOM; ANTI-MELITTIN ANTIBODIES; TICK SALIVARY PROTEIN; CROTALUS-ATROX VENOM; IXODES-RICINUS TICKS; HABU SNAKE VENOM;

D O I：

10.1016/j.molimm.2014.06.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nature is a wealthy source of agents that have been shown to be beneficial to human health, but nature is also a rich source of potential dangerous health damaging compounds. This review will summarise and discuss the agents from the animal kingdom that have been shown to interact with the human complement (C) system. Most of these agents are toxins found in animal venoms and animal secretions. In addition to the mechanism of action of these toxins, their contribution to the field of complement, their role in human pathology and the potential benefit to the venomous animal itself will be discussed. Potential therapeutic applications will also be discussed. (C) 2014 Elsevier Ltd. All rights reserved.

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收藏

页码：153 / 162

页数：10

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