Angiogenic Biomaterials to Promote Tissue Vascularization and Integration

被引:13
|
作者
Wells, Laura A. [1 ]
Valic, Michael S. [1 ]
Lisovsky, Alexandra [1 ]
Sefton, Michael V. [1 ,2 ]
机构
[1] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
[2] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3G9, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
angiogenesis; biomaterials; polyanions; polymers; METHYL METHACRYLATE) BEADS; SONIC HEDGEHOG; HYDROGEL SCAFFOLDS; CLOSE PROXIMITY; IN-VITRO; GROWTH; ACID; VEGF; ACTIVATION; NEOVASCULARIZATION;
D O I
10.1002/ijch.201300053
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Robert Langer's work with Judah Folkman brought angiogenesis into the spotlight and herein we focus on an offshoot of this work - biomaterial-driven therapeutic angiogenesis. Angiogenic biomaterials are expected to improve vascularization and integration in tissue engineering, wound healing and medical device applications. This review focuses on therapeutic methacrylic acid copolymers, highlighting some new approaches to use these materials. Such copolymers require no biological components (drugs or cells) to promote in vivo vascularization; they are therapeutic polymers.
引用
收藏
页码:637 / 645
页数:9
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