Resting-state slow wave power, healthy aging and cognitive performance

被引：134

作者：

Vlahou, Eleni L. ^{[1
]}

Thurm, Franka ^{[2
]}

Kolassa, Iris-Tatjana ^{[1
,3
]}

Schlee, Winfried ^{[1
,3
]}

机构：

[1] Univ Ulm, Inst Psychol & Educ, D-89069 Ulm, Germany

[2] Tech Univ Dresden, Dept Psychol, Dresden, Germany

[3] Univ Konstanz, Dept Psychol, Constance, Germany

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

HUMAN THETA-OSCILLATIONS; WORKING-MEMORY; ALZHEIMERS-DISEASE; TEMPORAL-LOBE; DEFAULT MODE; EEG; AGE; BRAIN; ALPHA; VOLUMES;

D O I：

10.1038/srep05101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cognitive functions and spontaneous neural activity show significant changes over the life-span, but the interrelations between age, cognition and resting-state brain oscillations are not well understood. Here, we assessed performance on the Trail Making Test and resting-state magnetoencephalographic (MEG) recordings from 53 healthy adults (18-89 years old) to investigate associations between age-dependent changes in spontaneous oscillatory activity and cognitive performance. Results show that healthy aging is accompanied by a marked and linear decrease of resting-state activity in the slow frequency range (0.5-6.5 Hz). The effects of slow wave power on cognitive performance were expressed as interactions with age: For older (>54 years), but not younger participants, enhanced delta and theta power in temporal and central regions was positively associated with perceptual speed and executive functioning. Consistent with previous work, these findings substantiate further the important role of slow wave oscillations in neurocognitive function during healthy aging.

引用

页数：6

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