Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly

被引：43

作者：

Chen, Yumin ^{[1
,5
]}

Deng, Ke ^{[1
]}

Lei, Shengbin ^{[2
,3
]}

Yang, Rong ^{[1
]}

Li, Tong ^{[4
]}

Gu, Yuantong ^{[4
]}

Yang, Yanlian ^{[1
]}

Qiu, Xiaohui ^{[1
]}

Wang, Chen ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Tianjin Univ, Dept Chem, Sch Sci, Tianjin 300072, Peoples R China

[3] Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China

[4] Queensland Univ Technol, Sch Chem Phys & Mech Engn, Brisbane, Qld 4000, Australia

[5] Chinese Acad Sci, Fujian Inst Res Struct Matter, Fuzhou 350002, Fujian, Peoples R China

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

CHIRAL RECOGNITION; AMPLIFICATION; ORIGIN;

D O I：

10.1038/s41467-018-05218-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Homochirality is very important in the formation of advanced biological structures, but the origin and evolution mechanisms of homochiral biological structures in complex hierarchical process is not clear at the single-molecule level. Here we demonstrate the single-molecule investigation of biological homochirality in the hierarchical peptide assembly, regarding symmetry break, chirality amplification, and chirality transmission. We find that homochirality can be triggered by the chirality unbalance of two adsorption configuration monomers. Co-assembly between these two adsorption configuration monomers is very critical for the formation of homochiral assemblies. The site-specific recognition is responsible for the subsequent homochirality amplification and transmission in their hierarchical assembly. These single-molecule insights open up inspired thoughts for understanding biological homochirality and have general implications for designing and fabricating artificial biomimetic hierarchical chiral materials.

引用

页数：8

共 34 条

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