General and facile synthesis of 1,2-amino alcohols

被引：4
|
作者：
Jung, DY [1 ]
Ko, CH [1 ]
Kim, YH [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Chem, Sch Mol Sci BK21, Ctr Mol Design & Synth, Taejon 305701, South Korea
来源：
SYNLETT | 2004年 / 07期
关键词：
amino alcohol; alpha-amidoalkyl phenylsulfone; benzyloxymethyl lithium; nucleophilic addition; activated imine;
D O I：
10.1055/s-2004-822926
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Facile preparation of 1,2-amino alcohols has been achieved by the reaction of benzyloxymethyl lithium with imines, which are generated from alpha-amido sulfones and benzyloxymethyl lithium in situ at -78degreesC in THF.
引用
收藏
页码：1315 / 1317
页数：3
相关论文
共 50 条
  • [31] Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums
    Hodgson, DM
    Stefane, B
    Miles, TJ
    Witherington, J
    CHEMICAL COMMUNICATIONS, 2004, (19) : 2234 - 2235
  • [32] Unsaturated 1,2-amino alcohols from dihydropyrrole epoxides and organolithiums
    Hodgson, DM
    Miles, TJ
    Witherington, J
    SYNLETT, 2002, (02) : 310 - 312
  • [33] A Practical Method for the Synthesis of Highly Enantioenriched trans-1,2-Amino Alcohols
    Birrell, James A.
    Jacobsen, Eric N.
    ORGANIC LETTERS, 2013, 15 (12) : 2895 - 2897
  • [34] Asymmetric Synthesis of Chiral 1,2-Amino Alcohols and Morpholin-2-ones from Arylglyoxals
    Powell, Wyatt C.
    Walczak, Maciej A.
    JOURNAL OF ORGANIC CHEMISTRY, 2018, 83 (17): : 10487 - 10500
  • [35] Multi-step synthesis strategies towards 1,2-amino alcohols with special emphasis on phenylpropanolamines
    Sehl, Torsten
    Maugeri, Zaira
    Rother, Doerte
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2015, 114 : 65 - 71
  • [36] Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines
    Tang, TP
    Volkman, SK
    Ellman, JA
    JOURNAL OF ORGANIC CHEMISTRY, 2001, 66 (26): : 8772 - 8778
  • [37] An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols
    Gupta, Pankaj
    Taneja, Subhash C.
    Shah, Bhahwal A.
    Mukherjee, Debaraj
    Parshad, Rajinder
    Chimni, Swapandeep S.
    Qazi, Ghulam N.
    TETRAHEDRON-ASYMMETRY, 2008, 19 (16) : 1898 - 1903
  • [38] Chiral 1,2-amino alcohols and 1,2-diamines derived from cyclohexene oxide: Recent applications in asymmetric synthesis
    de Parrodi, Cecilia Anaya
    Juaristi, Eusebio
    SYNLETT, 2006, (17) : 2699 - 2715
  • [39] Application of pyrrolo-protected amino aldehydes in the stereoselective synthesis of anti-1,2-amino alcohols
    Sauer, Maria
    Beemelmanns, Christine
    CHEMICAL COMMUNICATIONS, 2022, 58 (64) : 8990 - 8993
  • [40] Useful Applications of Enantioselective (4+2)-Cycloaddition Reactions to the Synthesis of Chiral 1,2-Amino Alcohols, 1,2-Diamines, and β-Amino Acids
    Reddy, Karla Mahender
    Thirupathi, Barla
    Corey, E. J.
    ORGANIC LETTERS, 2017, 19 (18) : 4956 - 4959
12345