General and facile synthesis of 1,2-amino alcohols

被引：4
|
作者：
Jung, DY [1 ]
Ko, CH [1 ]
Kim, YH [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Chem, Sch Mol Sci BK21, Ctr Mol Design & Synth, Taejon 305701, South Korea
来源：
SYNLETT | 2004年 / 07期
关键词：
amino alcohol; alpha-amidoalkyl phenylsulfone; benzyloxymethyl lithium; nucleophilic addition; activated imine;
D O I：
10.1055/s-2004-822926
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Facile preparation of 1,2-amino alcohols has been achieved by the reaction of benzyloxymethyl lithium with imines, which are generated from alpha-amido sulfones and benzyloxymethyl lithium in situ at -78degreesC in THF.
引用
收藏
页码：1315 / 1317
页数：3
相关论文
共 50 条
  • [21] EFFICIENT PREPARATION OF BIOLOGICALLY IMPORTANT 1,2-AMINO ALCOHOLS
    Gupta, Pankaj
    Rouf, Abdul
    Shah, Bhahwal A.
    Mukherjee, Debaraj
    Taneja, Subhash C.
    SYNTHETIC COMMUNICATIONS, 2013, 43 (04) : 505 - 519
  • [22] 1,2-amino alcohols by photocycloaddition ring opening sequences
    Schroder, J
    Bach, T
    JOURNAL OF INFORMATION RECORDING, 1998, 24 (3-4): : 285 - 288
  • [23] A waste-minimized protocol for the preparation of 1,2-azido alcohols and 1,2-amino alcohols
    Ballerini, Eleonora
    Crotti, Paolo
    Frau, Ileana
    Lanari, Daniela
    Pizzo, Ferdinando
    Vaccaro, Luigi
    GREEN CHEMISTRY, 2013, 15 (09) : 2394 - 2400
  • [24] Radical-mediated intramolecular β-C(sp3)-H amidation of alkylimidates: facile synthesis of 1,2-amino alcohols
    Mou, Xue-Qing
    Chen, Xiang-Yu
    Chen, Gong
    He, Gang
    CHEMICAL COMMUNICATIONS, 2018, 54 (05) : 515 - 518
  • [25] Synthesis and in vitro cytotoxicity of long chain 2-amino alcohols and 1,2-diamines
    Markidis, T
    Padron, JM
    Martin, VS
    Peters, GJ
    Kokotos, G
    ANTICANCER RESEARCH, 2001, 21 (4A) : 2835 - 2839
  • [26] Asymmetric synthesis of 1,2-amino alcohols using tert-butanesulfinimines as chiral auxiliary
    Ko, CH
    Jung, DY
    Kim, MK
    Kim, YH
    SYNLETT, 2005, (02) : 304 - 308
  • [27] Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids
    Hall, Christopher J. J.
    Goundry, William R. F.
    Donohoe, Timothy J.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (13) : 6981 - 6985
  • [28] Engineering Enzyme Substrate Scope Complementarity for Promiscuous Cascade Synthesis of 1,2-Amino Alcohols
    McDonald, Allwin D.
    Bruffy, Samantha K.
    Kasat, Aadhishre T.
    Buller, Andrew R.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (46)
  • [29] Synthesis of aromatic 1,2-amino alcohols utilizing a bienzymatic dynamic kinetic asymmetric transformation
    Steinreiber, Johannes
    Schuermann, Martin
    van Assema, Friso
    Wolberg, Michael
    Fesko, Kateryna
    Reisinger, Christoph
    Mink, Daniel
    Griengl, Herfried
    ADVANCED SYNTHESIS & CATALYSIS, 2007, 349 (8-9) : 1379 - 1386
  • [30] A Novel Dimeric BINOL for Enantioselective Recognition of 1,2-Amino Alcohols
    Velmurugan, Krishnaswamy
    Tang, Lijun
    Nandhakumar, Raju
    CHINESE JOURNAL OF CHEMISTRY, 2014, 32 (11) : 1157 - 1160
12345