Sexually Acquired Hepatitis C Infection in HIV-Uninfected Men Who Have Sex With Men Using Preexposure Prophylaxis Against HIV

被引：19

作者：

Price, Jennifer C. ^{[1
]}

McKinney, Jeffrey E. ^{[1
]}

Crouch, Pierre-Cedric ^{[2
]}

Dillon, Stephen M. ^{[3
]}

Radix, Asa ^{[4
]}

Stivala, Alicia ^{[4
]}

Carollo, Jesse R. ^{[5
]}

Fierer, Daniel S. ^{[5
]}

机构：

[1] Univ Calif San Francisco, Div Liver Dis, San Francisco, CA 94143 USA

[2] San Francisco AIDS Fdn, San Francisco, CA USA

[3] NYU, Langone Med Ctr, New York, NY 10003 USA

[4] Callen Lorde Community Hlth Ctr, New York, NY USA

[5] Icahn Sch Med Mt Sinai, Div Infect Dis, 1 Gustave L Levy Pl,Box 1009, New York, NY 10029 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 219卷 / 09期

关键词：

acute hepatitis C virus; men who have sex with men; preexposure prophylaxis; sexual transmission; methamphetamine; VIRUS; RISK; HCV;

D O I：

10.1093/infdis/jiy670

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sexually acquired hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)-uninfected men who have sex with men (MSM) have been rare. With the introduction of preexposure prophylaxis (PrEP) against HIV, we hypothesized that these infections would increase. Between 2013 and 2018, we diagnosed 15 likely sexually acquired HCV infections among 14 MSM using PrEP. Most (87%) were asymptomatic, detected by routine alanine transaminase (ALT) or HCV monitoring. Half reported increasing sex partners and drug use after starting PrEP; 5 reported injection of methamphetamine. Interventions are needed to prevent sexually acquired HCV infections by MSM using PrEP. Centers for Disease Control and Prevention guidelines for monitoring during PrEP should include regular ALT and HCV testing.

引用

页码：1373 / 1376

页数：4

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