Anticancer potential of docetaxel-loaded cobalt ferrite nanocarrier: an in vitro study on MCF-7 and MDA-MB-231 cell lines

被引：14
作者：
Panda, Jnanranjan [1 ]
Satapathy, Bhabani Sankar [2 ]
Mandal, Bidisha [1 ]
Sen, Ramkrishna [3 ]
Mukherjee, Biswajit [3 ]
Sarkar, Ratan [4 ]
Tudu, Bharati [1 ]
机构：
[1] Jadavpur Univ, Dept Phys, Kolkata 700032, India
[2] Siksha O Anusandhan Deemed Univ, Sch Pharmaceut Sci, Bhubaneswar, India
[3] Jadavpur Univ, Dept Pharmaceut Technol, Kolkata, India
[4] Jogesh Chandra Chaudhuri Coll, Dept Phys, Kolkata 700033, India
来源：
JOURNAL OF MICROENCAPSULATION | 2021年 / 38卷 / 01期
关键词：
Cobalt ferrite nanoparticles; breast cancer; docetaxel; cytotoxicity; biocompatibility;
D O I：
10.1080/02652048.2020.1842529
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Aim To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic acid and poly (d,l-lactide-co-glycolic) acid (PLGA) for the delivery of docetaxel (DTX) specifically to breast cancer cells. Methods The CF-NP were synthesised by hydrothermal method and conjugated with DTX in a PLGA matrix and were systematically characterised using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied. Results The CF-NP showed good crystallinity with an average particle size of 21 nm and ferromagnetic nature. The DTX-loaded CF-NP (DCF-NP) showed 8.4% (w/w) drug loading with 81.8% loading efficiency with a sustained DTX release over time. An effective internalisation and anti-proliferative efficiency was observed in MCF-7 and MDA-MB-231 breast cancer cells and negligible haemolytic effect. Conclusion The DCF-NP can have the potential for the effective delivery of DTX for breast cancer treatment.
引用
收藏
页码：36 / 46
页数：11
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