Characterization of the Corynebacterium glutamicum ΔpimB′ ΔmgtA Double Deletion Mutant and the Role of Mycobacterium tuberculosis Orthologues Rv2188c and Rv0557 in Glycolipid Biosynthesis

被引：25

作者：

Mishra, Arun K. ^{[1
]}

Batt, Sarah ^{[1
]}

Krumbach, Karin ^{[2
]}

Eggeling, Lothar ^{[2
]}

Besra, Gurdyal S. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[2] Forschungszentrum Julich, Inst Biotechnol 1, D-52425 Julich, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 13期

基金：

英国惠康基金;

关键词：

WALL ARABINAN BIOSYNTHESIS; PHOSPHATIDYLINOSITOL MANNOSIDES; IDENTIFICATION; MANNOSYLTRANSFERASE; ARABINOGALACTAN; ARABINOFURANOSYLTRANSFERASE; GENE; DEFICIENT; PROTEINS; SYNTHASE;

D O I：

10.1128/JB.01729-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, utilizing a Corynebacterium glutamicum Delta pimB' Delta mgtA double deletion mutant, we unequivocally assign the in vivo functions of Rv2188c as an Ac1PIM1: mannosyltransferase (originally termed PimB'(Mt) [Mycobacterium tuberculosis PimB']) and Rv0557 as a GlcAGroAc(2): mannosyltransferase (originally termed PimB(Mt)), which we have reassigned as PimBMt and MgtA(Mt), respectively, in Mycobacterium tuberculosis.

引用

页码：4465 / 4472

页数：8

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