A selective and light-up fluorescent probe for β-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative

被引：116

作者：

Jiang, Guoyu ^{[1
]}

Zeng, Guanjie ^{[1
]}

Zhu, Wenping ^{[1
]}

Li, Yongdong ^{[1
]}

Dong, Xiaobiao ^{[2
]}

Zhang, Guanxin ^{[2
]}

Fan, Xiaolin ^{[1
]}

Wang, Jianguo ^{[1
]}

Wu, Yongquan ^{[1
]}

Tang, Ben Zhong ^{[3
,4
]}

机构：

[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem, Ganzhou 341000, Peoples R China

[2] Chinese Acad Sci, Inst Chem, Organ Solids Lab, Beijing 100190, Peoples R China

[3] Hong Kong Univ Sci & Technol, Inst Adv Study, Inst Mol Funct Mat, Dept Chem, Kowloon, Hong Kong, Peoples R China

[4] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 32期

基金：

中国国家自然科学基金;

关键词：

AGGREGATION-INDUCED EMISSION; IN-VIVO VISUALIZATION; LACZ-GENE-EXPRESSION; TURN-ON; FUNCTIONALIZED TETRAPHENYLETHYLENE; RATIONAL DESIGN; REPORTER GENES; SENSOR; LUMINOGENS; COLOR;

D O I：

10.1039/c7cc00249a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An aggregation induced emission (AIE) based bioimaging probe, TPE-Gal, was designed for light-up imaging of beta-galactosidase in living cells. The applicability of TPE-Gal in imaging endogenous beta-galactosidase activity was confirmed in OVCAR-3 cells.

引用

页码：4505 / 4508

页数：4

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