Highly sensitive detection of paclitaxel by surface-enhanced Raman scattering

被引：16

作者：

Cottat, Maximilien ^{[1
]}

Lidgi-Guigui, Nathalie ^{[1
]}

Hamouda, Frederic ^{[2
]}

Bartenlian, Bernard ^{[2
]}

Venkataraman, Divya ^{[3
]}

Marks, Robert S. ^{[3
,4
]}

Steele, Terry W. J. ^{[3
]}

de la Chapelle, Marc Lamy ^{[1
]}

机构：

[1] Univ Paris 13, Sorbonne Paris Cite, Lab CSPBAT, CNRS,UMR 7244, F-93017 Bobigny, France

[2] Univ Paris 11, CNRS, IEF, UMR8622, F-91405 Orsay, France

[3] Nanyang Technol Univ, Sch Mat Sci & Engn, Mat Technol Div, Coll Engn, Singapore 639798, Singapore

[4] Ben Gurion Univ Negev, Avram & Stella Goldstein Goren Dept Biotechnol En, Natl Inst Biotechnol Negev, Ilse Katz Inst Nanosci & Technol, IL-84105 Beer Sheva, Israel

来源：

JOURNAL OF OPTICS | 2015年 / 17卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

SERS; biosensors; soft UV-NIL; nanoimprint; paclitaxel; NANOIMPRINT LITHOGRAPHY; GOLD NANOPARTICLES; SERS; SPECTROSCOPY; MOLECULE; ARRAYS;

D O I：

10.1088/2040-8978/17/11/114019

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The surface-enhanced Raman scattering (SERS) technique was shown to be an effective molecular analytical tool due to its high sensitivity. Here, we propose to exploit soft UV assisted nanoimprint lithography (UV-NIL) for the development of a reproducible and highly-sensitive SERS biosensor. Soft lithography is known to be advantageous for biological applications since it is compatible with insulating supports and large-area samples. In the present investigations, soft UV-NIL is used for the fabrication of large-sized arrays of gold nanocylinders on glass which were shown to be highly sensitive and highly specific sensing surfaces, with a limit of detection measured down to 1 nM. Employing the UV-NIL SERS substrate enable working ranges of nanomolar to micromolar concentrations in regards to our model paclitaxel analyte.

引用

页数：5

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