Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer

被引：90

作者：

Nasrin, Aklima ^{[1
]}

Hassan, Mahbub ^{[1
]}

Gomes, Vincent G. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem & Biomol Engn, Sydney, NSW 2006, Australia

来源：

NANOSCALE | 2020年 / 12卷 / 40期

关键词：

QUANTUM DOTS;

D O I：

10.1039/d0nr05210h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel conjugated carbon dots (CDs) were synthesized as two-photon active photosensitisers to unleash lethal reactive oxygen species (ROS) for nucleus-targeting photodynamic therapy (PDT). To enhance the therapeutic efficiency and preclude non-specific CD uptake, we employed a combination of folic acid and curcumin for two-photon NIR-triggered ROS generation and enhanced internalization in the nucleus. Consequently, enhanced destruction of cancer cells occurred by directly attacking the DNA. The intrinsic ROS generation and nucleus-targeting ability of CDs introduced multifunctional two-photon active nanoprobes within a single platform for enhanced PDT in oral cancer theranostics.

引用

页码：20598 / 20603

页数：6

共 23 条

[11] Diketopyrrolopyrrole-based carbon dots for photodynamic therapy [J].

He, Haozhe ;

Zheng, Xiaohua ;

Liu, Shi ;

Zheng, Min ;

Xie, Zhigang ;

Wang, Yong ;

Yu, Meng ;

Shuai, Xintao .

NANOSCALE, 2018, 10 (23) :10991-10998

[12] Cell Nucleus-Targeting Zwitterionic Carbon Dots [J].

Jung, Yun Kyung ;

Shin, Eeseul ;

Kim, Byeong-Su .

SCIENTIFIC REPORTS, 2015, 5

[13] Nucleus-staining with biomolecule-mimicking nitrogen-doped carbon dots prepared by a fast neutralization heat strategy [J].

Kang, Yan-Fei ;

Fang, Yang-Wu ;

Li, Yu-Hao ;

Li, Wen ;

Yin, Xue-Bo .

CHEMICAL COMMUNICATIONS, 2015, 51 (95) :16956-16959

[14] Excitation-independent carbon dot probes for exogenous and endogenous Fe3+ sensing in living cells: Fluorescence lifetime and sensing mechanism [J].

Lesani, Pooria ;

Ardekani, Sara Madadi ;

Dehghani, Alireza ;

Hassan, Mahbub ;

Gomes, Vincent G. .

SENSORS AND ACTUATORS B-CHEMICAL, 2019, 285 :145-155

[15] Porphyrin-Based Carbon Dots for Photodynamic Therapy of Hepatoma [J].

Li, Yang ;

Zheng, Xiaohua ;

Zhang, Xiaoyu ;

Liu, Shi ;

Pei, Qing ;

Zheng, Min ;

Xie, Zhigang .

ADVANCED HEALTHCARE MATERIALS, 2017, 6 (01)

[16] Carbon quantum dots and their applications [J].

Lim, Shi Ying ;

Shen, Wei ;

Gao, Zhiqiang .

CHEMICAL SOCIETY REVIEWS, 2015, 44 (01) :362-381

[17] Synthesis of Luminescent Carbon Dots with Ultrahigh Quantum Yield and Inherent Folate Receptor-Positive Cancer Cell Targetability [J].

Liu, Haifang ;

Li, Zhaohui ;

Sun, Yuanqiang ;

Geng, Xin ;

Hu, Yalei ;

Meng, Hongmin ;

Ge, Jia ;

Qu, Lingbo .

SCIENTIFIC REPORTS, 2018, 8

[18] Dumbbell-shaped carbon quantum dots/AuNCs nanohybrid as an efficient ratiometric fluorescent probe for sensing cadmium (II) ions and L-ascorbic acid [J].

Niu, Wen-Jun ;

Shan, Dan ;

Zhu, Rong-Hui ;

Deng, Sheng-Yuan ;

Cosnier, Serge ;

Zhang, Xue-Ji .

CARBON, 2016, 96 :1034-1042

[19] Curcumin-mediated Photodynamic Therapy for the treatment of oral infections-A review [J].

Santezi, Carolina ;

Reina, Barbara Donadon ;

Dovigo, Livia Nordi .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2018, 21 :409-415

[20] DNA Nuclear Targeting Sequences for Non-Viral Gene Delivery [J].

van Gaal, Ethlinn V. B. ;

Oosting, Ronald S. ;

van Eijk, Roel ;

Bakowska, Marta ;

Feyen, Dries ;

Kok, Robbert Jan ;

Hennink, Wim E. ;

Crommelin, Daan J. A. ;

Mastrobattista, Enrico .

PHARMACEUTICAL RESEARCH, 2011, 28 (07) :1707-1722

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