Two-photon active nucleus-targeting carbon dots: enhanced ROS generation and photodynamic therapy for oral cancer

被引：90

作者：

Nasrin, Aklima ^{[1
]}

Hassan, Mahbub ^{[1
]}

Gomes, Vincent G. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem & Biomol Engn, Sydney, NSW 2006, Australia

来源：

NANOSCALE | 2020年 / 12卷 / 40期

关键词：

QUANTUM DOTS;

D O I：

10.1039/d0nr05210h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel conjugated carbon dots (CDs) were synthesized as two-photon active photosensitisers to unleash lethal reactive oxygen species (ROS) for nucleus-targeting photodynamic therapy (PDT). To enhance the therapeutic efficiency and preclude non-specific CD uptake, we employed a combination of folic acid and curcumin for two-photon NIR-triggered ROS generation and enhanced internalization in the nucleus. Consequently, enhanced destruction of cancer cells occurred by directly attacking the DNA. The intrinsic ROS generation and nucleus-targeting ability of CDs introduced multifunctional two-photon active nanoprobes within a single platform for enhanced PDT in oral cancer theranostics.

引用

页码：20598 / 20603

页数：6

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