The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): Development and assessment of reliability

被引：79

作者：

Charidimou, Andreas ^{[1
,2
,5
]}

Schmitt, Anne ^{[2
,3
]}

Wilson, Duncan ^{[1
,2
]}

Yakushiji, Yusuke ^{[1
,2
]}

Gregoire, Simone M. ^{[1
,2
]}

Fox, Zoe ^{[4
,5
]}

Jager, Hans R. ^{[1
,2
,3
]}

Werring, David J. ^{[1
,2
]}

机构：

[1] UCL Inst Neurol, UCL Stroke Res Ctr, Queen Sq, London WC1N 3BG, England

[2] Natl Hosp Neurol & Neurosurg, Queen Sq, London WC1N 3BG, England

[3] UCL Inst Neurol, Lysholm Dept Neuroradiol, London, England

[4] UCL Inst Neurol, Educ Unit, Biomed Res Ctr, Queen Sq, London WC1N 3BG, England

[5] Massachusetts Gen Hosp, Harvard Med Sch, Hemorrhag Stroke Res Grp, Boston, MA 02114 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2017年 / 372卷

关键词：

Stroke; Intracerebral haemorrhage; CT; MRI; Cerebral amyloid angiopathy; SMALL VESSEL DISEASE; INTRACEREBRAL HEMORRHAGE; AMYLOID ANGIOPATHY; AGREEMENT; STROKE; GUIDELINES; MAP;

D O I：

10.1016/j.jns.2016.11.021

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: The causes, risk factors and prognosis of spontaneous intracerebral haemorrhage (ICH) are partly determined by anatomical location (specifically, lobar vs. non-lobar (deep and infratentorial) regions). We systematically developed a rating instrument to reliably classify ICH location. Methods: We used a two-stage iterative Delphi-style method for instrument development. The resultant Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS) was validated on CT and MRI scans from a cohort of consecutive patients with acute spontaneous symptomatic ICH by three independent raters. We tested interrater and intrarater reliability using kappa statistics. Results: Our validation cohort included 227 patients (58% male; median age: 72.4 (IQR: 67.1-74.6)). The interrater reliability for the main analyses (i.e. including any lobar ICH; all deep and infratentorial anatomical categories (lentiform, caudate thalamus; brainstem; cerebellum); and uncertain location) was excellent (all kappa values > 0.80) both in pair-wise between-rater comparisons and across all raters. The intrarater reliability was substantial to almost perfect (k = 0.83; 95%CI: 0.77-0.88 and k = 0.95; 95%CI: 0.92-0.96 respectively). All kappa statistics remained consistent for individual cerebral lobar regions. Conclusions: The CHARTS instrument can be used to reliably and comprehensively map the anatomical location of spontaneous ICH, and may be helpful for studying important questions regarding causes, risk factors, prognosis, and for stratification in clinical trials. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：178 / 183

页数：6

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