Fluorescence studies of the nicotinic acetylcholine receptor in its membrane environment

被引：1

作者：

Barrantes, FJ ^{[1
]}

Antollini, S ^{[1
]}

Massol, R ^{[1
]}

机构：

[1] Univ Nacl Sur, Inst Invest Bioquim Bahia Blanca, RA-8000 Bahia Blanca, Buenos Aires, Argentina

来源：

BIOSCIENCE REPORTS | 1999年 / 19卷 / 05期

关键词：

cell surface receptors; cholinergic receptor; lipid-protein interactions; Laurdan; annular lipids;

D O I：

10.1023/A:1020247802798

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the discovery of the fraction of immobilized lipid in contact with the nicotinic acetylcholine receptor (AChR), the lipid-belt region around this protein has become the focus of a variety of biophysical studies aimed at defining its properties. Here we summarize recent spectroscopic studies from our laboratory using Laurdan fluorescence to characterize distinct sites for lipids and to describe their effect on the AChR microenvironment.

引用

页码：335 / 344

页数：10

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