The Impact of African Ancestry on Prostate Cancer Disparities in the Era of Precision Medicine

被引：24

作者：

Lewis, Deyana D. ^{[1
]}

Cropp, Cheryl D. ^{[2
]}

机构：

[1] NHGRI, Computat & Stat Genom Branch, Baltimore, MD 21224 USA

[2] Samford Univ, Dept Pharmaceut Social & Adm Sci, McWhorter Sch Pharm, Birmingham, AL 35229 USA

来源：

GENES | 2020年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

prostate cancer; genetics; health disparity; African ancestry; clinical trials; GENOME-WIDE ASSOCIATION; ANDROGEN RECEPTOR GENE; BRCA2 MUTATION CARRIERS; CAG REPEAT LENGTH; 8Q24 RISK ALLELES; AMERICAN MEN; SOCIOECONOMIC-STATUS; CYP17; GENE; SUSCEPTIBILITY LOCUS; CLINICAL-TRIALS;

D O I：

10.3390/genes11121471

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Prostate cancer disproportionately affects men of African ancestry at nearly twice the rate of men of European ancestry despite the advancement of treatment strategies and prevention. In this review, we discuss the underlying causes of these disparities including genetics, environmental/behavioral, and social determinants of health while highlighting the implications and challenges that contribute to the stark underrepresentation of men of African ancestry in clinical trials and genetic research studies. Reducing prostate cancer disparities through the development of personalized medicine approaches based on genetics will require a holistic understanding of the complex interplay of non-genetic factors that disproportionately exacerbate the observed disparity between men of African and European ancestries.

引用

页码：1 / 28

页数：28

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