Evidence for a T-lymphocyte dependent mechanism involving proinflammatory cytokines in anticonvulsant hypersensitivity syndrome: A case report.

被引：23

作者：

Chiappini, E ^{[1
]}

Peruzzi, M ^{[1
]}

Galli, L ^{[1
]}

Calabri, G ^{[1
]}

de Martino, M ^{[1
]}

机构：

[1] Univ Florence, Anna Meyer Childrens Hosp, Dept Paediat, Div Paediat & Infect Dis, I-50132 Florence, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2002年 / 15卷 / 03期

关键词：

anticonvulsant hypersensitivity syndrome; phenobarbital; interleukin-6; T-lymphocytes;

D O I：

10.1177/039463200201500311

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anticonvulsant drug hypersensitivity syndrome (AHS) is a potentially fatal drug reaction associated with aromatic antiepileptic drugs, the pathogenic mechanisms of which are still unclear. We studied a 2-year-old female affected with AHS after phenobarbital treatment. In vitro experiments showed a T-lymphocyte response to the drug and an increased, dose-related, IL-6 production after drug incubation. These findings suggest that AHS may be caused by a T-lymphocyte dependent mechanism, involving pro-inflammatory cytokines.

引用

页码：239 / 242

页数：4

共 16 条

[1] Antonen J, 1999, J RHEUMATOL, V26, P2585
[2] Belli F, 2000, INT J IMMUNOPATH PH, V13, P61
[3] Benoni G, 2001, INT J IMMUNOPATH PH, V14, P161
[4] Drug-induced hypersensitivity syndrome in pediatric patients
Carroll, MC
Yueng-Yue, NB
Esterly, NB
Drolet, BA
[J]. PEDIATRICS, 2001, 108 (02) : 485 - 493
[5] Drug allergy diagnosis in humans: possibilities and pitfalls
Choquet-Kastylevsky, G
Vial, T
Descotes, J
[J]. TOXICOLOGY, 2001, 158 (1-2) : 1 - 10
[6] Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock
Dinarello, CA
[J]. CHEST, 1997, 112 (06) : 321S - 329S
[7] Proinflammatory cytokines
Dinarello, CA
[J]. CHEST, 2000, 118 (02) : 503 - 508
[8] Extrapolation of experimental safety data to humans: The interleukin-6 case
Kammuller, M
Ryffel, B
[J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1997, 83 (01): : 15 - 17
[9] Kasahara S, 2001, INT J IMMUNOPATH PH, V14, P63
[10] Anticonvulsant hypersensitivity syndrome - Incidence, prevention and management
Knowles, SR
Shapiro, LE
Shear, NH
[J]. DRUG SAFETY, 1999, 21 (06) : 489 - 501

← 1 2 →