Cytotoxicity and membrane perturbation associated with the myristylated N-terminal portion of HIV-1 Gag protein

被引：0
|
作者：
Curtain, CC [1 ]
Macreadie, IG [1 ]
机构：
[1] Biomol Res Inst, Parkville, Vic 3052, Australia
来源：
PROTEIN AND PEPTIDE LETTERS | 2000年 / 7卷 / 01期
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中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Gag and Nef proteins of human immunodeficiency type 1 (HIV-1) have conserved N-terminal sequences that appear essential for HIV-1 function. In view of the structural similarities a Gag peptide corresponding to myrGag(2-22), was subjected to cytotoxicity tests employing recently developed cell assays. The Gag peptide displays a similar activity to Nef. The role of such sequences may be important in viral membrane association, viral biogenesis and transition of these proteins through the cellular membrane.
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页码：37 / 42
页数：6
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