Basic immunology of antibody targeted radiotherapy

被引：11

作者：

Wong, Jeffrey Y. C.

机构：

[1] City Hope Natl Med Ctr, Div Radiat Oncol, Duarte, CA 91010 USA

[2] Beckman Res Inst, Duarte, CA USA

来源：

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2006年 / 66卷 / 02期

关键词：

radioimmunotherapy; antibodies; STaRT; radionuclide;

D O I：

10.1016/j.ijrobp.2005.05.056

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antibody targeted radiotherapy brings an important new treatment modality to the radiation oncology clinic. Radiation dose to tumor and normal tissues are determined by a complex interplay of antibody, antigen, tumor, radionuclide, and host-related factors. A basic understanding of these immunologic and physiologic factors is important to optimally utilize this therapy in the clinic. Preclinical and clinical studies need to be continued to broaden our understanding and to develop new strategies to further improve the efficacy of this promising form of targeted therapy. (c) 2006 Elsevier Inc.

引用

页码：S8 / S14

页数：7

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