Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives

被引：56

作者：

Cetinkaya, Yasin ^{[1
,2
]}

Gocer, Hulya ^{[3
]}

Goksu, Suleyman ^{[1
]}

Gulcin, Ilhami ^{[1
]}

机构：

[1] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey

[2] Ataturk Univ, Oltu Vocat Sch, Dept Food Technol, TR-25240 Erzurum, Turkey

[3] Ibrahim Cecen Univ Agri, Cent Res Lab, Agri, Turkey

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2014年 / 29卷 / 02期

关键词：

Benzylamine; carbonic anhydrase; enzyme inhibition; sulfonamide; ERYTHROCYTE ISOZYMES I; VITRO; ACETAZOLAMIDE; PERSPECTIVE; TARGETS; SERIES;

D O I：

10.3109/14756366.2012.763163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthesis and carbonic anhydrase inhibitory properties of novel diarylmethylamines 22-25 and sulfonamide derivatives 26-28 were investigated. Acylation of methoxy-substituted benzenes with benzene carboxylic acids, reduction of ketones with NaBH4, conversion of alcohols to azides, Pd-C catalyzed hydrogenation of azides afforded title compounds 22-25. Compounds 22, 24 and 25 were converted to sulfonamide derivatives 26-28 with MeSO2Cl. The inhibitory effects of novel benzylamine derivatives 22-28 were tested on human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes hCA I and II. The results demonstrated that compound 28 was found to be the best inhibitor against both hCA I (K-i: 3.68 mM) and hCA II (K-i: 9.23 mM).

引用

页码：168 / 174

页数：7

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