The Influence of Intervertebral Disc Microenvironment on the Biological Behavior of Engrafted Mesenchymal Stem Cells

被引：12
作者：
Zhang, Jing [1 ]
Zhang, Wentao [1 ]
Sun, Tianze [1 ]
Wang, Jinzuo [1 ]
Li, Ying [2 ]
Liu, Jing [2 ]
Li, Zhonghai [1 ,2 ]
机构：
[1] Dalian Med Univ, Dept Orthoped, Affiliated Hosp 1, Dalian 116011, Liaoning, Peoples R China
[2] Dalian Med Univ, Stem Cell Clin Res Ctr, Natl Joint Engn Lab, Affiliated Hosp 1, Dalian 116021, Liaoning, Peoples R China
来源：
STEM CELLS INTERNATIONAL | 2022年 / 2022卷
关键词：
NUCLEUS PULPOSUS CELLS; CYCLIC HYDROSTATIC-PRESSURE; BONE-MARROW; PROGENITOR CELLS; ADIPOSE-TISSUE; DYNAMIC COMPRESSION; IN-VITRO; CHONDROGENIC DIFFERENTIATION; PROMOTES CHONDROGENESIS; STROMAL CELLS;
D O I：
10.1155/2022/8671482
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Intervertebral disc degeneration is the main cause of low back pain. Traditional treatment methods cannot repair degenerated intervertebral disc tissue. The emergence of stem cell therapy makes it possible to regenerate and repair degenerated intervertebral disc tissue. At present, mesenchymal stem cells are the most studied, and different types of mesenchymal stem cells have their own characteristics. However, due to the harsh and complex internal microenvironment of the intervertebral disc, it will affect the biological behaviors of the implanted mesenchymal stem cells, such as viability, proliferation, migration, and chondrogenic differentiation, thereby affecting the therapeutic effect. This review is aimed at summarizing the influence of each intervertebral disc microenvironmental factor on the biological behavior of mesenchymal stem cells, so as to provide new ideas for using tissue engineering technology to assist stem cells to overcome the influence of the microenvironment in the future.
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页数：24
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