Synthetic antibody technologies

被引：49

作者：

Adams, Jarrett J.

Sidhu, Sachdev S. ^{[1
]}

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5S 3E1, Canada

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2014年 / 24卷

关键词：

BROADLY NEUTRALIZING ANTIBODIES; FULL-LENGTH KCSA; SURFACE DISPLAY; SELECTION; ANTIGEN; RECOGNITION; LIBRARY; DIVERSITY; SEQUENCE; RECEPTOR;

D O I：

10.1016/j.sbi.2013.11.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic antibody technologies enable the rapid production of affinity reagents through in vitro selections. The production of synthetic antibodies relies on sophisticated design strategies to produce combinatorial diversity libraries that encode antibody populations optimized for molecular recognition. The technology takes advantage of display technologies that enable amplification, selection and manipulation of antibodies in vitro. The rapid yet highly controlled nature of these methods has opened new avenues in basic and clinical research. Here we review recent advances in structural biology facilitated by synthetic antibodies, as well as advances in library designs and selection methods.

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页码：1 / 9

页数：9

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