Pathogenesis of necrotising enterocolitis: The impact of the altered gut microbiota and antibiotic exposure in preterm infants

被引：27

作者：

Raba, Ali Ahmed ^{[1
,2
]}

O'Sullivan, Anne ^{[2
]}

Miletin, Jan ^{[1
,2
,3
,4
]}

机构：

[1] UCD Sch Med & Med Sci, Dublin, Ireland

[2] Coombe Women & Infants Univ Hosp, Cork St, Dublin 8, Ireland

[3] Inst Care Mother & Child, Prague, Czech Republic

[4] Charles Univ Prague, Sch Med 3, Prague, Czech Republic

来源：

ACTA PAEDIATRICA | 2021年 / 110卷 / 02期

关键词：

antibiotics; microbiota; necrotising enterocolitis; preterm infants; BIRTH-WEIGHT INFANTS; INTENSIVE-CARE-UNIT; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; SEPSIS; HEALTH; RISK; ESTABLISHMENT; ASSOCIATION; COMMUNITIES;

D O I：

10.1111/apa.15559

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Necrotising enterocolitis (NEC) is a devastating condition with high morbidity and mortality seen predominately in preterm infants. Multiple factors are associated with the pathogenesis of NEC. The widespread use of antibiotics in the neonatal intensive care unit might play a role in the pathogenesis of NEC in preterm infants. This review provides a summary on the intestinal microbiota in preterm infants with a focus on how antibiotic exposure may reduce the biodiversity of the intestinal microbiota and may predispose preterm infants to NEC. Conclusion Prolonged antibiotic therapy has been suggested as a risk factor for the development of NEC in preterm infants.

引用

页码：433 / 440

页数：8

共 83 条

[41]

KENYON S, 2013, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD001058.PUB3

[42] Maternal intrapartum antibiotics and decreased vertical transmission of Lactobacillus to neonates during birth [J].

Keski-Nisula, Leea ;

Kyynarainen, Hanna-Reetta ;

Karkkainen, Ulla ;

Karhukorpi, Jari ;

Heinonen, Seppo ;

Pekkanen, Juha .

ACTA PAEDIATRICA, 2013, 102 (05) :480-485

[43] Intestinal microbiota development and gestational age in preterm neonates [J].

Korpela, Katri ;

Blakstad, Elin W. ;

Moltu, Sissel J. ;

Strommen, Kenneth ;

Nakstad, Britt ;

Ronnestad, Arild E. ;

Braekke, Kristin ;

Iversen, Per O. ;

Drevon, Christian A. ;

de Vos, Willem .

SCIENTIFIC REPORTS, 2018, 8

[44] Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature Infants [J].

Kuppala, Venkata S. ;

Meinzen-Derr, Jareen ;

Morrow, Ardythe L. ;

Schibler, Kurt R. .

JOURNAL OF PEDIATRICS, 2011, 159 (05) :720-725

[45] Patterned progression of bacterial populations in the premature infant gut [J].

La Rosa, Patricio S. ;

Warner, Barbara B. ;

Zhou, Yanjiao ;

Weinstock, George M. ;

Sodergren, Erica ;

Hall-Moore, Carla M. ;

Stevens, Harold J. ;

Bennett, William E., Jr. ;

Shaikhb, Nurmohammad ;

Linneman, Laura A. ;

Hoffmann, Julie A. ;

Hamvas, Aaron ;

Deych, Elena ;

Shands, Berkley A. ;

Shannon, William D. ;

Tarr, Phillip I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (34) :12522-12527

[46] Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects [J].

Le Huerou-Luron, Isabelle ;

Blat, Sophie ;

Boudry, Gaelle .

NUTRITION RESEARCH REVIEWS, 2010, 23 (01) :23-36

[47] Diversity, stability and resilience of the human gut microbiota [J].

Lozupone, Catherine A. ;

Stombaugh, Jesse I. ;

Gordon, Jeffrey I. ;

Jansson, Janet K. ;

Knight, Rob .

NATURE, 2012, 489 (7415) :220-230

[48] Normal neonatal microbiome variation in relation to environmental factors, infection and allergy [J].

Madan, Juliette C. ;

Farzan, Shohreh F. ;

Hibberd, Patricia L. ;

Karagas, Margaret R. .

CURRENT OPINION IN PEDIATRICS, 2012, 24 (06) :753-759

[49] The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota [J].

Milani, Christian ;

Duranti, Sabrina ;

Bottacini, Francesca ;

Casey, Eoghan ;

Turroni, Francesca ;

Mahony, Jennifer ;

Belzer, Clara ;

Delgado Palacio, Susana ;

Arboleya Montes, Silvia ;

Mancabelli, Leonardo ;

Lugli, Gabriele Andrea ;

Miguel Rodriguez, Juan ;

Bode, Lars ;

de Vos, Willem ;

Gueimonde, Miguel ;

Margolles, Abelardo ;

van Sinderen, Douwe ;

Ventura, Marco .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2017, 81 (04)

[50]

Mitchell C, 2020, BIORXIV 2020 2020 01

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