Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens

被引：48
作者：
Liu, Xia [1 ,2 ]
Yang, Xing-Wei [1 ,2 ]
Chen, Chao-Qun [1 ]
Wu, Chun-Yan [1 ]
Zhang, Jing-Jing [1 ,2 ]
Ma, Jun-Zeng [1 ]
Wang, Huan [1 ]
Yang, Li-Xin [1 ]
Xu, Gang [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期
关键词：
HENRYI SUBSP URALOIDES; HYPERFORIN; BENZOPHENONES;
D O I：
10.1021/np400287r
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B D (1-3) exhibited moderate inhibitory activity (IC50 5.8-17.9 mu M) against the tested tumor cell lines.
引用
收藏
页码：1612 / 1618
页数：7
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