Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens

被引：48
作者：
Liu, Xia [1 ,2 ]
Yang, Xing-Wei [1 ,2 ]
Chen, Chao-Qun [1 ]
Wu, Chun-Yan [1 ]
Zhang, Jing-Jing [1 ,2 ]
Ma, Jun-Zeng [1 ]
Wang, Huan [1 ]
Yang, Li-Xin [1 ]
Xu, Gang [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期
关键词：
HENRYI SUBSP URALOIDES; HYPERFORIN; BENZOPHENONES;
D O I：
10.1021/np400287r
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Nine new polyprenylated acylphloroglucinol derivatives, hypercohins B-J (1-9), and nine known analogues were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-9 were elucidated based on spectroscopic analysis, and the absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B D (1-3) exhibited moderate inhibitory activity (IC50 5.8-17.9 mu M) against the tested tumor cell lines.
引用
收藏
页码：1612 / 1618
页数：7
相关论文
共 50 条
  • [31] Hyperpatulones A-F, polycyclic polyprenylated acylphloroglucinols from Hypericum patulum and their cytotoxic activities
    Wu, Zhong-Nan
    Niu, Qian-Wen
    Zhang, Yu-Bo
    Luo, Ding
    Li, Qing-Guo
    Li, Ying-Ying
    Kuang, Guang-Kai
    He, Li-Jun
    Wang, Guo-Cai
    Li, Yao-Lan
    [J]. RSC ADVANCES, 2019, 9 (14): : 7961 - 7966
  • [32] Hyperbeanols F-Q, diverse monoterpenoid polyprenylated acylphloroglucinols from the flowers of Hypericum beanii
    Li, Yi-Ran
    Xu, Wen-Jun
    Wei, Shan-Shan
    Lu, Wei-Jia
    Luo, Jun
    Kong, Ling-Yi
    [J]. PHYTOCHEMISTRY, 2019, 159 : 56 - 64
  • [33] Unusual adamantane type polyprenylated acylphloroglucinols with an oxirane unit and their structural transformation from Hypericum hookerianum
    Ye, Ye
    Yang, Xing-Wei
    Xu, Gang
    [J]. TETRAHEDRON, 2016, 72 (22) : 3057 - 3062
  • [34] Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides
    Chen, Xuan-Qin
    Li, Yan
    Cheng, Xiao
    Wang, Kou
    He, Juan
    Pan, Zheng-Hong
    Li, Ming-Ming
    Peng, Li-Yan
    Xu, Gang
    Zhao, Qin-Shi
    [J]. CHEMISTRY & BIODIVERSITY, 2010, 7 (01) : 196 - 204
  • [35] Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii
    Zhu, Hucheng
    Chen, Chunmei
    Yang, Jing
    Li, Xiao-Nian
    Liu, Junjun
    Sun, Bin
    Huang, Sheng-Xiong
    Li, Dongyan
    Yao, Guangmin
    Luo, Zengwei
    Li, Yan
    Zhang, Jinwen
    Xue, Yongbo
    Zhang, Yonghui
    [J]. ORGANIC LETTERS, 2014, 16 (24) : 6322 - 6325
  • [36] Hypermongones A-J, Rare Methylated Polycyclic Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum
    Xu, Wen-Jun
    Zhu, Meng-Di
    Wang, Xiao-Bing
    Yang, Ming-Hua
    Luo, Jun
    Kong, Ling-Yi
    [J]. JOURNAL OF NATURAL PRODUCTS, 2015, 78 (05): : 1093 - 1100
  • [37] Cytotoxic Polyprenylated Benzoylphloroglucinol Derivatives from the Branches of Garcinia schomburgkiana
    Kaennakam, Sutin
    Sukandar, Edwin Risky
    Rassamee, Kitiya
    Siripong, Pongpun
    Tip-pyang, Santi
    [J]. PLANTA MEDICA, 2023, 89 (05) : 508 - 515
  • [38] Antimicrobial Evaluation of Two Polycyclic Polyprenylated Acylphloroglucinol Compounds: PPAP23 and PPAP53
    Ammanath, Aparna Viswanathan
    Matsuo, Miki
    Wang, Huanhuan
    Kraus, Frank
    Bleisch, Anton
    Peslalz, Philipp
    Mohammad, Majd
    Deshmukh, Meghshree
    Griesshammer, Anne
    Purkayastha, Moushumi
    Vorbach, Andreas
    Macek, Boris
    Broetz-Oesterhelt, Heike
    Maier, Lisa
    Kretschmer, Dorothee
    Peschel, Andreas
    Jin, Tao
    Plietker, Bernd
    Goetz, Friedrich
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (15)
  • [39] Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum
    Gao, Wan
    Hu, Jia-Wen
    Xu, Fang
    Wei, Can-Jing
    Shi, Meng-Jiao
    Zhao, Jun
    Wang, Jia-Jia
    Zhen, Bo
    Ji, Teng-Fei
    Xing, Jian-Guo
    Gu, Zheng-Yi
    Xu, Fang
    [J]. FITOTERAPIA, 2016, 115 : 128 - 134
  • [40] Anti-Inflammatory, Antioxidant, and Anti-Nonalcoholic Steatohepatitis Acylphloroglucinol Meroterpenoids from Hypericum bellum Flowers
    Zhou, Xin
    Xu, Wenjun
    Li, Yiran
    Zhang, Meihui
    Tang, Pengfei
    Lu, Weijia
    Li, Qiji
    Zhang, Hao
    Luo, Jun
    Kong, Lingyi
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 69 (02) : 646 - 654
12345