Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis

被引：80
|
作者：
Ibrahim, Ashraf S. [1 ,2 ]
Gebremariam, Teclegiorgis
Schwartz, Julie A. [3 ]
Edwards, John E., Jr. [2 ]
Spellberg, Brad [2 ]
机构：
[1] Harbor UCLA Med Ctr, Div Infect Dis, Los Angeles Biomed Res Inst, St Johns Cardiovasc Res Ctr, Torrance, CA 90502 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] Charles River Labs, Davis, CA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期
关键词：
IMPROVES SURVIVAL; RHIZOPUS-ORYZAE; AMPHOTERICIN-B; SALVAGE THERAPY; MICE; MUCORMYCOSIS;
D O I：
10.1128/AAC.01124-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.
引用
收藏
页码：772 / 775
页数：4
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