Posaconazole Mono- or Combination Therapy for Treatment of Murine Zygomycosis

被引：80

作者：

Ibrahim, Ashraf S. ^{[1
,2
]}

Gebremariam, Teclegiorgis

Schwartz, Julie A. ^{[3
]}

Edwards, John E., Jr. ^{[2
]}

Spellberg, Brad ^{[2
]}

机构：

[1] Harbor UCLA Med Ctr, Div Infect Dis, Los Angeles Biomed Res Inst, St Johns Cardiovasc Res Ctr, Torrance, CA 90502 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[3] Charles River Labs, Davis, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 02期

关键词：

IMPROVES SURVIVAL; RHIZOPUS-ORYZAE; AMPHOTERICIN-B; SALVAGE THERAPY; MICE; MUCORMYCOSIS;

D O I：

10.1128/AAC.01124-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared the efficacy of combination posaconazole-liposomal amphotericin B (LAmB) therapy to monotherapy with either drug in diabetic ketoacidotic or neutropenic mice with disseminated zygomycosis caused by Rhizopus oryzae. Combination therapy was no better than LAmB alone, and posaconazole monotherapy did not improve survival or reduce fungal burden versus placebo.

引用

页码：772 / 775

页数：4

共 15 条

[1] Activity of posaconazole in treatment of experimental disseminated zygomycosis [J].

Dannaoui, E ;

Meis, JFGM ;

Loebenberg, D ;

Verweij, PE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (11) :3647-3650

[2] Posaconazole as salvage therapy for zygomycosis [J].

Greenberg, RN ;

Mullane, K ;

van Burik, JAH ;

Raad, I ;

Abzug, MJ ;

Anstead, G ;

Herbrecht, R ;

Langston, A ;

Marr, KA ;

Schiller, G ;

Schuster, M ;

Wingard, JR ;

Gonzalez, CE ;

Revankar, SG ;

Corcoran, G ;

Kryscio, RJ ;

Hare, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (01) :126-133

[3] Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae [J].

Ibrahim, AS ;

Avanessian, V ;

Spellberg, B ;

Edwards, JE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (10) :3343-3344

[4] Caspofungin inhibits rhizopus oryzae 1,3-β-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis [J].

Ibrahim, AS ;

Bowman, JC ;

Avanessian, V ;

Brown, K ;

Spellberg, B ;

Edwards, JE ;

Douglas, CM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :721-727

[5] Combination echinocandin-polyene treatment of murine mucormycosis [J].

Ibrahim, Ashraf S. ;

Gebremariam, Teclegiorgis ;

Fu, Yue ;

Edwards, John E., Jr. ;

Spellberg, Brad .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (04) :1556-1558

[6] The iron chelator deferasirox protects mice from mucormycosis through iron starvation [J].

Ibrahim, Ashraf S. ;

Gebermariam, Teclegiorgis ;

Fu, Yue ;

Lin, Lin ;

Husseiny, Mohamed I. ;

French, Samuel W. ;

Schwartz, Julie ;

Skory, Christopher D. ;

Edwards, John E., Jr. ;

Spellbergl, Brad J. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) :2649-2657

[7] Deferiprone iron chelation as a novel therapy for experimental mucormycosis [J].

Ibrahim, Ashraf S. ;

Edwards, John E., Jr. ;

Fu, Yue ;

Spellberg, Brad .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (05) :1070-1073

[8]

Kwon-Chung KJ., 1992, MED MYCOL, P524

[9] Epidemiology and outcome of zygomycosis: A review of 929 reported cases [J].

Roden, MM ;

Zaoutis, TE ;

Buchanan, WL ;

Knudsen, TA ;

Sarkisova, TA ;

Schaufele, RL ;

Sein, M ;

Sein, T ;

Chiou, CC ;

Chu, JH ;

Kontoyiannis, DP ;

Walsh, TJ .

CLINICAL INFECTIOUS DISEASES, 2005, 41 (05) :634-653

[10] Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae [J].

Rodriguez, M. Mar ;

Serena, Carolina ;

Marine, Marcal ;

Pastor, F. Javier ;

Guarro, Josep .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (10) :3786-3788

← 1 2 →