Molecular regulation of galectin-3 expression and therapeutic implication in cancer progression

被引：69

作者：

Wang, Lei ^{[1
]}

Guo, Xiu-Li ^{[1
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, 44 Wen Hua Xi Rd, Jinan 250012, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2016年 / 78卷

基金：

美国国家科学基金会;

关键词：

Galectin-3; Regulation mechanism; Transcription factors; Inflammatory cytokines; Ras/MAPK pathway; Cancer; PROSTATE-CANCER; CIRCULATING GALECTIN-3; DECREASED EXPRESSION; TUMOR PROGRESSION; SERUM GALECTIN-3; GENE-EXPRESSION; BINDING LECTIN; CELLS; METASTASIS; PROTEIN;

D O I：

10.1016/j.biopha.2016.01.014

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Galectin-3, a multifunctional protein, distributes inside and outside cells and plays an important role in tumor cell adhesion, proliferation, differentiation, angiogenesis, and metastasis in multiple tumors. Changes in galectin-3 expression are commonly seen in cancer and pre-cancerous conditions. Therefore, to understand the molecular regulation of galectin-3 expression could aid the development of new approach for cancer treatment. This review summarizes different expression of galectin-3 in cancer cells and patients' serum, the regulation mechanism and the potential therapeutic targets of galectin-3 in cancer progression. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：165 / 171

页数：7

共 77 条

[1] Increased galectin-3 expression in gastric cancer:: Correlations with histopathological subtypes, galactosylated antigens and tumor cell proliferation [J].