Current advancements and future perspectives of immunotherapy in colorectal cancer research

被引：104

作者：

Kishore, Chandra ^{[1
]}

Bhadra, Priyanka ^{[2
]}

机构：

[1] Fatki Kutti, Life Sci Bldg, Patna 847408, Bihar, India

[2] Boral Tripursundari Rd, Kolkata 700154, W Bengal, India

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2021年 / 893卷

关键词：

Colorectal cancer; Immunotherapy; dMMR-MSI-H; pMMR-MSI-L; Immune checkpoint inhibitor; T-cells; PD-1; BLOCKADE; TUMOR-CELLS; T-CELLS; PHASE-I; CTLA-4; NIVOLUMAB; THERAPY; ACTIVATION; MECHANISMS; RECEPTORS;

D O I：

10.1016/j.ejphar.2020.173819

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

5-Fluorouracil (5-FU) is the first-line chemotherapy drug for colorectal cancer but most of the patients get resistant to the drug on a longer course of treatment. After the successful use of immunotherapy in melanoma treatment, it was explored with enthusiasm in different types of solid cancers including colorectal cancer. Nivolumab and pembmlizumab (Programmed cell death-1 blocking antibodies) have shown efficacy in the mismatch repair deficient high microsatellite instability (dMMR-MSI-H) subtype of metastatic colorectal cancer (CRC) patients. Immunotherapy has shown long time remission in a subset of metastatic CRC patients. The molecular mechanism and emerging roles of immunotherapy in colorectal cancer are explored in this review article and future directions for the proper utilization of the development in immunobiology are suggested.

引用

页数：7

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