A facile synthesis of 2,5-disubstituted oxazoles via a copper-catalyzed cascade reaction of alkenes with azides

被引：33
作者：
Li, Jiu-ling [1 ]
Wang, Ying-chun [1 ,2 ]
Li, Wei-ze [1 ]
Wang, Heng-shan [1 ]
Mo, Dong-liang [1 ]
Pan, Ying-ming [1 ]
机构：
[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, Key Lab Chem & Mol Engn Med Resources, Minist Educ China, Guilin 541004, Peoples R China
[2] Jishou Univ, Coll Chem & Chem Engn, Jishou 416000, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 100期
基金：
中国国家自然科学基金;
关键词：
ONE-POT SYNTHESIS; 2,4,5-TRISUBSTITUTED OXAZOLES; REGIOSELECTIVE SYNTHESIS; SUBSTITUTED OXAZOLES; THIAZOLE ALKALOIDS; OXIDATION; NITRILES; SYSTEMS; ALKYNES; ARYL;
D O I：
10.1039/c5cc06487b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and efficient approach to the synthesis of 2,5-disubstituted oxazoles is developed via a 1,3-dipolar cycloaddition/ring cleavage/1,2-H migration/denitrogenation/copper-catalyzed aerobic oxidative dehydrogenative cyclization cascade. The desired products can be obtained from readily available aromatic terminal alkenes and azides employing air as the oxidant under mild conditions, and it offers an attractive alternative method for the synthesis of oxazole derivatives.
引用
收藏
页码：17772 / 17774
页数：3
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