Copper-Catalyzed Formal Dehydrogenative Coupling of Carbonyls with Polyfluoroarenes Leading to β-C-H Arylation

被引：31

作者：

Xie, Weilong ^{[1
,2
]}

Kim, Dongwook ^{[1
,2
]}

Chang, Sukbok ^{[1
,2
]}

机构：

[1] Inst for Basic Sci Korea, Ctr Catalyt Hydrocarbon Functionalizat, Daejeon 34141, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 34141, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 49期

关键词：

MUKAIYAMA ALDOL REACTION; ELECTRON-DEFICIENT; FUNCTIONALIZATION; ALLYLATION; PHARMACEUTICALS; ALKENYLATION; ALKYLARENES; FLUORINE; KETONES; BONDS;

D O I：

10.1021/jacs.0c10904

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We herein communicate a formal dehydrogenative coupling of carbonyls with polyfluoroarenes enabled by Cu catalysis. Silyl enol ethers initially prepared from carbonyls are postulated to undergo the copper-mediated oxidative dehydrogenative coupling with polyfluoroarenes via a radical pathway. Including cyclic and linear ketones, aldehydes, and esters, a broad range of beta-aryl carbonyl products were efficiently obtained in high regio- and stereoselectivity with excellent functional group tolerance.

引用

页码：20588 / 20593

页数：6

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