Hepatic stellate cell: A star cell in the liver

被引：117
作者：
Atzori, Luigi [1 ]
Poli, Giuseppe [2 ]
Perra, Andrea [1 ]
机构：
[1] Univ Cagliari, Dept Toxicol, Oncol Mol Pathol Unit, I-09124 Cagliari, Italy
[2] Univ Turin, San Luigi Hosp, Dept Clin & Biol Sci, I-10043 Turin, Italy
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2009年 / 41卷 / 8-9期
关键词：
Hepatic stellate cells; Myofibroblasts; Extracellular matrix; Liver fibrosis; PROLIFERATION; ACTIVATION; FIBROSIS; DISEASE;
D O I：
10.1016/j.biocel.2009.03.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hepatic stellate cells represent a highly versatile cytotype that plays a significant role in liver development and differentiation, regeneration, xenobiotic response, immunoregulation, control of hepatic blood flow and inflammatory reactions. Because of the wide panel of molecular intermediates they may produce and secrete, particularly after their sustained activation in a disease state, hepatic stellate cells are definitely involved in the pathogenesis of various liver pathologies, besides the well know key role in fibrosis and extracellular matrix remodelling. In particular, they can actively contribute to the progression of hepatitis and steatohepatitis of different aetiology, and of liver carcinogenesis. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1639 / 1642
页数：4
相关论文
共 27 条
[1]   Angiotensin II induces contraction and proliferation of human hepatic stellate cells [J].
Bataller, R ;
Ginès, P ;
Nicolás, JM ;
Görbig, MN ;
Garcia-Ramallo, E ;
Gasull, X ;
Bosch, J ;
Arroyo, V ;
Rodés, J .
GASTROENTEROLOGY, 2000, 118 (06) :1149-1156
[2]   Extracellular matrix degradation and the role of hepatic stellate cells [J].
Benyon, RC ;
Arthur, MJP .
SEMINARS IN LIVER DISEASE, 2001, 21 (03) :373-384
[3]   Human hepatic stellate cells express class I alcohol dehydrogenase and aldehyde dehydrogenase but not cytochrome P4502E1 [J].
Casini, A ;
Pellegrini, G ;
Ceni, E ;
Salzano, R ;
Parola, M ;
Robino, G ;
Milani, S ;
Dianzani, MU ;
Surrenti, C .
JOURNAL OF HEPATOLOGY, 1998, 28 (01) :40-45
[4]   Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver [J].
Friedman, Scott L. .
PHYSIOLOGICAL REVIEWS, 2008, 88 (01) :125-172
[5]   On the origin of stellate cells: mesodermal, endodermal or neuro-ectodermal? [J].
Geerts, A .
JOURNAL OF HEPATOLOGY, 2004, 40 (02) :331-334
[6]   THE LIPOCYTES IN NORMAL HUMAN-LIVER - A QUANTITATIVE STUDY [J].
GIAMPIERI, MP ;
JEZEQUEL, AM ;
ORLANDI, F .
DIGESTION, 1981, 22 (04) :165-&
[7]   Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets [J].
Gressner, A. M. ;
Weiskirchen, R. .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2006, 10 (01) :76-99
[8]   Desmin expressing nonhematopoietic liver cells during rat liver development: An immunohistochemical and morphometric study [J].
Kiassov, AP ;
VanEyken, P ;
vanPelt, JF ;
Depla, E ;
Fevery, J ;
Desmet, VJ ;
Yap, PSH .
DIFFERENTIATION, 1995, 59 (04) :253-258
[9]   CD133+ hepatic stellate cells are progenitor cells [J].
Kordes, Claus ;
Sawitza, Iris ;
Mueller-Marbach, Alexis ;
Ale-Agha, Niloofar ;
Keitel, Verena ;
Klonowski-Stumpe, Hanne ;
Haeussinger, Dieter .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 352 (02) :410-417
[10]   CELLULAR SOURCES OF GLUTATHIONE-S-TRANSFERASE-P IN PRIMARY CULTURED RAT HEPATOCYTES - LOCALIZATION BY IN-SITU HYBRIDIZATION [J].
LEE, SJ ;
FRIEDMAN, SL ;
WHALEN, R ;
BOYER, TD .
BIOCHEMICAL JOURNAL, 1994, 299 :79-83
123