Evaluation of leptin level and Ob gene polymorphism in patients with Behcet's disease

被引：5
作者：
Okudan, Nilsel
Acar, Hasan
Gokbel, Hakki [1 ]
Mevlitoglu, Inci
Sari, Fatih
机构：
[1] Selcuk Univ, Dept Physiol, Meram Fac Med, TR-42080 Konya, Turkey
[2] Selcuk Univ, Dept Med Genet, Meram Fac Med, TR-42080 Konya, Turkey
[3] Selcuk Univ, Dept Dermatol, Meram Fac Med, TR-42080 Konya, Turkey
来源：
ARCHIVES OF DERMATOLOGICAL RESEARCH | 2006年 / 298卷 / 03期
关键词：
Behcet's disease; leptin; Ob gene; polymorphism;
D O I：
10.1007/s00403-006-0669-x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The present study was aimed to evaluate serum leptin level and the frequency of oligopolymorphic codon 25 (CAA/CAG) of Ob gene in Behcet's disease. Eighty-seven patients with Behcet's disease and 85 healthy controls with matched age, gender and body mass index were included in the study. Serum leptin level was determined and genotype of codon 25 of Ob gene was performed by using the PCR amplification after DNA extraction. Serum leptin concentration of the patients with Behcet's disease (23.8 +/- 22.8 ng/ml) was higher than that of the control groups (17.1 +/- 14.7 ng/ml). The patients with Behcet's disease and control subjects showed CAA/CAA genotype, indicating the presence of no polymorphism. Neither Behcet's disease nor serum leptin level was found to be related to codon 25 polymorphism. We concluded that leptin 25CAG polymorphism is not associated with Behcet's disease and serum leptin level.
引用
收藏
页码：127 / 130
页数：4
相关论文
共 35 条
[1]   Mapping the HLA association in Behcet's disease - A role for tumor necrosis factor polymorphisms? [J].
Ahmad, T ;
Wallace, GR ;
James, T ;
Neville, M ;
Bunce, M ;
Mulcahy-Hawes, K ;
Armuzzi, A ;
Crawshaw, J ;
Fortune, F ;
Walton, R ;
Stanford, MR ;
Welsh, KI ;
Marshall, SE ;
Jewell, DP .
ARTHRITIS AND RHEUMATISM, 2003, 48 (03) :807-813
[2]  
Akdeniz N, 2004, ANN ACAD MED SINGAP, V33, P596
[3]  
Behçet H, 1937, DERMATOL WOCHENSCHR, V105, P1152
[4]  
Boiardi L, 2001, J RHEUMATOL, V28, P1283
[5]   Characterization of single-nucleotide polymorphisms in coding regions of human genes [J].
Cargill, M ;
Altshuler, D ;
Ireland, J ;
Sklar, P ;
Ardlie, K ;
Patil, N ;
Lane, CR ;
Lim, EP ;
Kalyanaraman, N ;
Nemesh, J ;
Ziaugra, L ;
Friedland, L ;
Rolfe, A ;
Warrington, J ;
Lipshutz, R ;
Daley, GQ ;
Lander, ES .
NATURE GENETICS, 1999, 22 (03) :231-238
[6]   Linkages and associations between the leptin receptor (LEPR) gene and human body composition in the Quebec Family Study [J].
Chagnon, YC ;
Chung, WK ;
Pérusse, L ;
Chagnon, M ;
Leibel, RL ;
Bouchard, C .
INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (03) :278-286
[7]   Specific interleukin-1 gene polymorphisms in Turkish patients with Behcet's disease [J].
Coskun, M ;
Bacanli, A ;
Sallakci, N ;
Alpsoy, E ;
Yavuzer, U ;
Yegin, O .
EXPERIMENTAL DERMATOLOGY, 2005, 14 (02) :124-129
[8]   Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity [J].
Evereklioglu, C ;
Inalöz, HS ;
Kirtak, N ;
Doganay, S ;
Bülbül, M ;
Otlu, B ;
Özerol, E ;
Er, H ;
Özbek, E .
BRITISH JOURNAL OF DERMATOLOGY, 2002, 147 (02) :331-336
[9]  
Frassanito MA, 1999, ARTHRITIS RHEUM, V42, P1967, DOI 10.1002/1529-0131(199909)42:9<1967::AID-ANR24>3.0.CO
[10]  
2-Z
1234