Synthesis and anticonvulsant activity of some (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones

被引：19

作者：

Çakir, B

Yildirim, E

Ercanli, T

Erol, K

Sahin, MF ^{[1
]}

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey

[2] Osmangazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey

来源：

FARMACO | 1999年 / 54卷 / 11-12期

关键词：

anticonvulsant activity; acetohydrazones; pentylenetetrazole;

D O I：

10.1016/S0014-827X(99)00110-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：842 / 845

页数：4

共 9 条

[1]

DALKARA S, 1988, J PHARM BELG, V43, P372

[2] SYNTHESIS OF 2-OXO-3-BENZOTHIAZOLINEACETYL CHLORIDE(7), 5-CHLORO-2-OXO-3-BENZOTHIAZOLINEACETYL CHLORIDE(8) AND DERIVATIVES [J].