Smart chemistry in polymeric nanomedicine

被引：157

作者：

Tong, Rong ^{[1
]}

Tang, Li ^{[1
]}

Ma, Liang ^{[1
]}

Tu, Chunlai ^{[1
]}

Baumgartner, Ryan ^{[2
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2014年 / 43卷 / 20期

关键词：

RING-OPENING POLYMERIZATION; BLOCK-COPOLYMER MICELLES; FREE CLICK CHEMISTRY; NONVIRAL GENE DELIVERY; CROSS-LINKED MICELLES; ACID-DERIVED POLY(ANHYDRIDE-ESTERS); DYNAMIC COMBINATORIAL CHEMISTRY; MESOPOROUS SILICA NANOPARTICLES; TRANSFER RADICAL POLYMERIZATION; INDICATOR-DISPLACEMENT ASSAYS;

D O I：

10.1039/c4cs00133h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review provides an overview of smart chemistry developed and utilized in the last 5-10 years in polymer-based drug delivery nanomedicine. Smart chemistry not only facilitates the controlled drug loading in a highly specific manner, but also potentially controls the drug release kinetics at the targeted tissues. This review highlights the emergence of new chemistry or unique utilization of conventional chemistry in drug delivery, which believed to play an important role in developing next generation nanomedicine.

引用

页码：6982 / 7012

页数：31

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