Mechanics of T cell receptor gene rearrangement

被引：173
作者：
Krangel, Michael S. [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 02期
基金：
美国国家卫生研究院;
关键词：
TCR-GAMMA-LOCUS; CHROMOSOMAL V(D)J RECOMBINATION; SEGMENT CHROMATIN-STRUCTURE; BETA ALLELIC EXCLUSION; EARLY-ALPHA TEA; GERMLINE TRANSCRIPTION; CHAIN GENE; INTERLEUKIN-7; RECEPTOR; ACCESSIBILITY CONTROL; THYMOCYTE DEVELOPMENT;
D O I：
10.1016/j.coi.2009.03.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The four T cell receptor genes (Tcra, Tcrb, Tcrg, Tcrd) are assembled by V(D)J recombination according to distinct programs during intrathymic T cell development. These programs depend on genetic factors, including gene segment order and recombination signal sequences. They also depend on epigenetic factors. Regulated changes in chromatin structure, directed by enhancers and promoter, can modify the availability of recombination signal sequences to the RAG recombinase. Regulated changes in locus conformation may control the synapsis of distant recombination signal sequences, and regulated changes in subnuclear positioning may influence locus recombination events by unknown mechanisms. Together these influences may explain the ordered activation and inactivation of T cell receptor locus recombination events and the phenomenon of Tcrb allelic exclusion.
引用
收藏
页码：133 / 139
页数：7
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