Contribution to the development of oral dosage form for insulin delivery

被引:0
作者
Vauthier, C [1 ]
Seiller, M [1 ]
Weingarten, C [1 ]
Couvreur, P [1 ]
机构
[1] Univ Paris 11, Lab Physicochim Pharmacotechnie & Biopharm, UMR CNRS 8612, F-92296 Chatenay Malabry, France
来源
STP PHARMA SCIENCES | 1999年 / 9卷 / 05期
关键词
insulin; nanocapsules; multiple emulsions; liposomes; oral administration; rat;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This paper reviews the contribution of Francis Puisieux and his group to one of the greatest challenges in pharmaceutical science, namely: the development of an oral dosage form for insulin. We place twenty years of research research by Professor Puisieux and his colleagues in the context of a global effort to solve the problem of oral insulin. This review traces their work with liposomes, multiple emulsions and nanoparticles as insulin vehicles for oral delivery.
引用
收藏
页码:391 / 396
页数:6
相关论文
共 68 条
[1]  
Aboubakar M, 1999, J BIOMED MATER RES, V47, P568, DOI 10.1002/(SICI)1097-4636(19991215)47:4<568::AID-JBM14>3.0.CO
[2]  
2-X
[3]  
Banting FG, 1922, J LAB CLIN MED, V7, P251
[4]   The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins [J].
Bernkop-Schnurch, A .
JOURNAL OF CONTROLLED RELEASE, 1998, 52 (1-2) :1-16
[5]   Oral insulin delivery [J].
Carino, GP ;
Mathiowitz, E .
ADVANCED DRUG DELIVERY REVIEWS, 1999, 35 (2-3) :249-257
[6]  
Chetty DJ, 1998, CRIT REV THER DRUG, V15, P629
[7]   NANOPARTICLES AND MICROPARTICLES FOR THE DELIVERY OF POLYPEPTIDES AND PROTEINS [J].
COUVREUR, P ;
PUISIEUX, F .
ADVANCED DRUG DELIVERY REVIEWS, 1993, 10 (2-3) :141-162
[8]  
COUVREUR P, 1998, PROGR CLIN PHARM FUT, P25
[9]   Insulin in w/o/w multiple emulsions: Preparation, characterization and determination of stability towards proteases in vitro [J].
Cunha, AS ;
Grossiord, JL ;
Puisieux, F ;
Seiller, M .
JOURNAL OF MICROENCAPSULATION, 1997, 14 (03) :311-319
[10]  
CUNHA AS, 1998, MULTIPLE EMULSIONS S, P279