An immunohistochemical study of p53 protein expression in classical Kaposi's sarcoma

被引:15
|
作者
Bergman, R
Ramon, M
Kilim, S
Lichtig, C
FriedmanBirnbaum, R
机构
[1] RAMBAM MED CTR, DEPT PATHOL, IL-31096 HAIFA, ISRAEL
[2] RAMBAM MED CTR, DERMATOPATHOL UNIT, IL-31096 HAIFA, ISRAEL
[3] TECHNION ISRAEL INST TECHNOL, BRUCE RAPPAPORT FAC MED, IL-31096 HAIFA, ISRAEL
关键词
Kaposi; p53; protein; immunohistochemistry; classical;
D O I
10.1097/00000372-199608000-00007
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The present study was performed to determine the frequency of p53 protein immunoreactivity in classical Kaposi's sarcoma (KS) as a whole and in relation to the histological subtypes which are considered to correspond to the developmental stages of the tumor. The accumulation of p53 protein was studied immunohistochemically using monoclonal antibody BP53-12 on formalin-fixed paraffin-embedded sections of 36 KS lesions, of which 14 were classified histologically as early type and 22 as spindle-cell or mixed type. No positive immunoreactivity was detected in any of the 14 early-type lesions. Among the 22 spindle-cell and mixed variants, positive staining was detected in 5-10% of the tumor cells in one lesion, 1-5% of the cells in six lesions, and in <1% of the cells in two lesions. These very small percentages of positively stained cells in less than half of the cases of the spindle-cell and mixed variants do not support a significant role for p53 in tumor progression and evolution in KS.
引用
收藏
页码:367 / 370
页数:4
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