A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes

被引：14

作者：

Cabler, Stephanie S. ^{[1
,2
]}

French, Anthony R. ^{[3
]}

Orvedahl, Anthony ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pediat, Div Infect Dis, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pediat, Div Crit Care Med, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Pediat, Div Rheumatol, St Louis, MO 63110 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2020年 / 26卷 / 12期

关键词：

COVID-19; DISEASE; CHILDREN;

D O I：

10.1016/j.molmed.2020.09.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An unbridled host immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to underlie severe cases of the disease and has been labeled a 'cytokine storm syndrome' (CSS). Here, we emphasize that categorization of syndromes triggered by a completely novel pathogen based on other seemingly similar, but potentially distinct, known entities is an inherently risky endeavor.

引用

页码：1078 / 1085

页数：8

共 33 条

[1] SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020 [J].

Belot, Alexandre ;

Antona, Denise ;

Renolleau, Sylvain ;

Javouhey, Etienne ;

Hentgen, Veronique ;

Angoulvant, Francois ;

Delacourts, Christophe ;

Iriart, Xavier ;

Ovaert, Caroline ;

Bader-Meunier, Brigitte ;

Kone-Paut, Isabelle ;

Levy-Bruhl, Daniel .

EUROSURVEILLANCE, 2020, 25 (22) :2-7

[2] Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 [J].

Blanco-Melo, Daniel ;

Nilsson-Payant, Benjamin E. ;

Liu, Wen-Chun ;

Uhl, Skyler ;

Hoagland, Daisy ;

Moller, Rasmus ;

Jordan, Tristan X. ;

Oishi, Kohei ;

Panis, Maryline ;

Sachs, David ;

Wang, Taia T. ;

Schwartz, Robert E. ;

Lim, Jean K. ;

Albrecht, Randy A. ;

tenOever, Benjamin R. .

CELL, 2020, 181 (05) :1036-+

[3] Clinical and immunological features of severe and moderate coronavirus disease 2019 [J].

Chen, Guang ;

Wu, Di ;

Guo, Wei ;

Cao, Yong ;

Huang, Da ;

Wang, Hongwu ;

Wang, Tao ;

Zhang, Xiaoyun ;

Chen, Huilong ;

Yu, Haijing ;

Zhang, Xiaoping ;

Zhang, Minxia ;

Wu, Shiji ;

Song, Jianxin ;

Chen, Tao ;

Han, Meifang ;

Li, Shusheng ;

Luo, Xiaoping ;

Zhao, Jianping ;

Ning, Qin .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05) :2620-2629

[4] Clinical progression of patients with COVID-19 in Shanghai, China [J].

Chen, Jun ;

Qi, Tangkai ;

Liu, Li ;

Ling, Yun ;

Qian, Zhiping ;

Li, Tao ;

Li, Feng ;

Xu, Qingnian ;

Zhang, Yuyi ;

Xu, Shuibao ;

Song, Zhigang ;

Zeng, Yigang ;

Shen, Yinzhong ;

Shi, Yuxin ;

Zhu, Tongyu ;

Lu, Hongzhou .

JOURNAL OF INFECTION, 2020, 80 (05) :E1-E6

[5] Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis [J].

Chinn, Ivan K. ;

Eckstein, Olive S. ;

Peckham-Gregory, Erin C. ;

Goldberg, Baruch R. ;

Forbes, Lisa R. ;

Nicholas, Sarah K. ;

Mace, Emily M. ;

Vogel, Tiphanie P. ;

Abhyankar, Harshal A. ;

Diaz, Maria I. ;

Heslop, Helen E. ;

Krance, Robert A. ;

Martinez, Caridad A. ;

Nguyen, Trung C. ;

Bashir, Dalia A. ;

Goldman, Jordana R. ;

Stray-Pedersen, Asbjorg ;

Pedroza, Luis A. ;

Poli, M. Cecilia ;

Aldave-Becerra, Juan C. ;

McGhee, Sean A. ;

Al-Herz, Waleed ;

Chamdin, Aghiad ;

Coban-Akdemir, Zeynep H. ;

Jhangiani, Shalini N. ;

Muzny, Donna M. ;

Cao, Tram N. ;

Hong, Diana N. ;

Gibbs, Richard A. ;

Lupski, James R. ;

Orange, Jordan S. ;

McClain, Kenneth L. ;

Allen, Carl E. .

BLOOD, 2018, 132 (01) :89-100

[6] The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19 [J].

Consiglio, Camila Rosat ;

Cotugno, Nicola ;

Sardh, Fabian ;

Pou, Christian ;

Amodio, Donato ;

Rodriguez, Lucie ;

Tan, Ziyang ;

Zicari, Sonia ;

Ruggiero, Alessandra ;

Pascucci, Giuseppe Rubens ;

Santilli, Veronica ;

Campbell, Tessa ;

Bryceson, Yenan ;

Eriksson, Daniel ;

Wang, Jun ;

Marchesi, Alessandra ;

Lakshmikanth, Tadepally ;

Campana, Andrea ;

Villani, Alberto ;

Rossi, Paolo ;

Landegren, Nils ;

Palma, Paolo ;

Brodin, Petter .

CELL, 2020, 183 (04) :968-+

[7] Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study [J].

Cummings, Matthew J. ;

Baldwin, Matthew R. ;

Abrams, Darryl ;

Jacobson, Samuel D. ;

Meyer, Benjamin J. ;

Balough, Elizabeth M. ;

Aaron, Justin G. ;

Claassen, Jan ;

Rabbani, LeRoy E. ;

Hastie, Jonathan ;

Hochman, Beth R. ;

Salazar-Schicchi, John ;

Yip, Natalie H. ;

Brodie, Daniel ;

O'Donnell, Max R. .

LANCET, 2020, 395 (10239) :1763-1770

[8] Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS CoV-2 [J].

Diorio, Caroline ;

Henrickson, Sarah E. ;

Vella, Laura A. ;

McNerney, Kevin O. ;

Chase, Julie ;

Burudpakdee, Chakkapong ;

Lee, Jessica H. ;

Jasen, Cristina ;

Balamuth, Fran ;

Barrett, David M. ;

Banwell, Brenda L. ;

Bernt, Kathrin M. ;

Blatz, Allison M. ;

Chiotos, Kathleen ;

Fisher, Brian T. ;

Fitzgerald, Julie C. ;

Gerber, Jeffrey S. ;

Gollomp, Kandace ;

Gray, Christopher ;

Grupp, Stephan A. ;

Harris, Rebecca M. ;

Kilbaugh, Todd J. ;

John, Audrey R. Odom ;

Lambert, Michele ;

Liebling, Emily J. ;

Paessler, Michele E. ;

Petrosa, Whitney ;

Phillips, Charles ;

Reilly, Anne F. ;

Romberg, Neil D. ;

Seif, Alix ;

Sesok-Pizzini, Deborah A. ;

Sullivan, Kathleen E. ;

Vardaro, Julie ;

Behrens, Edward M. ;

Teachey, David T. ;

Bassiri, Hamid .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (11) :5967-5975

[9] Multisystem Inflammatory Syndrome in Children in New York State [J].

Dufort, Elizabeth M. ;

Koumans, Emilia H. ;

Chow, Eric J. ;

Rosenthal, Elizabeth M. ;

Muse, Alison ;

Rowlands, Jemma ;

Barranco, Meredith A. ;

Maxted, Angela M. ;

Rosenberg, Eli S. ;

Easton, Delia ;

Udo, Tomoko ;

Kumar, Jessica ;

Pulver, Wendy ;

Smith, Lou ;

Hutton, Brad ;

Blog, Debra ;

Zucker, Howard .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) :347-358

[10] Multisystem Inflammatory Syndrome in US Children and Adolescents [J].

Feldstein, Leora R. ;

Rose, Erica B. ;

Horwitz, Steven M. ;

Collins, Jennifer P. ;

Newhams, Margaret M. ;

Son, Mary Beth F. ;

Newburger, Jane W. ;

Kleinman, Lawrence C. ;

Heidemann, Sabrina M. ;

Martin, Amarilis A. ;

Singh, Aalok R. ;

Li, Simon ;

Tarquinio, Keiko M. ;

Jaggi, Preeti ;

Oster, Matthew E. ;

Zackai, Sheemon P. ;

Gillen, Jennifer ;

Ratner, Adam J. ;

Walsh, Rowan F. ;

Fitzgerald, Julie C. ;

Keenaghan, Michael A. ;

Alharash, Hussam ;

Doymaz, Sule ;

Clouser, Katharine N. ;

Giuliano, John S. ;

Gupta, Anjali ;

Parker, Robert M. ;

Maddux, Aline B. ;

Havalad, Vinod ;

Ramsingh, Stacy ;

Bukulmez, Hulya ;

Bradford, Tamara T. ;

Smith, Lincoln S. ;

Tenforde, Mark W. ;

Carroll, Christopher L. ;

Riggs, Becky J. ;

Gertz, Shira J. ;

Daube, Ariel ;

Lansell, Amanda ;

Coronado Munoz, Alvaro ;

Hobbs, Charlotte V. ;

Marohn, Kimberly L. ;

Halasa, Natasha B. ;

Patel, Manish M. ;

Randolph, Adrienne G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) :334-346

← 1 2 3 4 →