Synthesis, X-ray structure, antiproliferative activity, interaction with HSA and docking studies of three novel mono and binuclear copper complexes containing the maltol ligand

被引:4
作者
Eraj, Malihe Zahmati [1 ]
Eriksson, Lars [2 ]
Alibolandi, Mona [3 ]
Babaei, Maryam [3 ]
Saljooghi, Amir Sh [1 ]
Ramezani, Mohammad [3 ]
机构
[1] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad 917751436, Razavi Khorasan, Iran
[2] Stockholm Univ, Dept Mat & Environm Chem, SE-10691 Stockholm, Sweden
[3] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran
关键词
HUMAN SERUM-ALBUMIN; DNA-BINDING; MOLECULAR DOCKING; ANTICANCER ACTIVITY; CRYSTAL-STRUCTURE; SPECTROSCOPIC CHARACTERIZATION; BIOLOGICAL-PROPERTIES; CYTOTOXIC ACTIVITIES; METAL-COMPLEXES; II COMPLEXES;
D O I
10.1039/d0nj03552a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The present study aims at synthesizing three new copper(ii) complexes of maltol in the presence of 1,10-phenanthroline-, 2,2 '-bipyridine- and 4,4-dibromo-2,2 '-bipyridine ligands. The structure of the Cu(ii) complexes was characterized by FTIR, CHN analysis and X-ray crystallography. The interaction of the Cu(ii) complexes with human serum albumin (HSA) was studied using various methods including fluorescence spectroscopy, UV-visible spectroscopy and molecular docking. The cytotoxic activity of the complexes was investigated using human breast cancer cells (MCF-7), and the results were compared with the activity of cis-platin as a positive control. The data showed that the complex 1, [Cu(mal)(4,4-dibromo-2,2 '-bpy)(H2O)]center dot NO3, has the highest cytotoxicity among the compounds. The experiment indicated that the quenching process of HSA fluorescence by complexes 1-4 and the maltol ligand is a static mechanism. In addition, the results provided information about thermodynamic parameters and the number of binding sites. The high values of K-b show that the complexes can bind strongly with HSA. The results from the UV-Visible spectroscopy studies demonstrated that conformational alterations occurred in the secondary structure of HSA due to binding with the complexes.
引用
收藏
页码:20101 / 20114
页数:14
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