Low rate of COVID-19 seroconversion in health-care workers at a Department of Infectious Diseases in Sweden during the later phase of the first wave; a prospective longitudinal seroepidemiological study

被引:23
作者
Rashid-Abdi, Mulki [1 ]
Krifors, Anders [1 ,2 ,3 ]
Salleber, Andreas [4 ]
Eriksson, Jenny [4 ]
Mansson, Emeli [1 ,3 ]
机构
[1] Hosp Vastmanland, Dept Infect Dis, Vasteras, Sweden
[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
[3] Uppsala Univ, Hosp Vastmanland, Ctr Clin Res Vastmanland, Vasteras, Sweden
[4] Hosp Vastmanland, Dept Clin Microbiol, Vasteras, Sweden
关键词
COVID-19; health-care workers; seroprevalence; SARS-CoV-2;
D O I
10.1080/23744235.2020.1849787
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Health-care workers are at risk of contracting and transmitting SARS-CoV-2. The aim of this study was to investigate the prevalence of SARS-CoV-2 IgG antibodies and the rate of seroconversion in an environment with high exposure to SARS-CoV-2. Methods: 131 health-care workers at the Department of Infectious Diseases in Vasteras, Sweden, were included in the study. Abbott's SARS-COV-2 IgG immunoassay was used with a signal cut-off ratio of >= 1.4. Every third week from the beginning of May, blood samples were drawn, and the participants completed a questionnaire regarding symptoms consistent with COVID-19 and the result of any SARS-CoV-2 PCR performed since the last sampling occasion. Participants with IgG antibodies against SARS-CoV-2 were re-sampled only on the sixth and last occasion. Results: At the start of the study, 18 (15%) participants had SARS-CoV-2 IgG antibodies. At the end, 25 (19%) of 131 participants were seropositive. One case of asymptomatic infection was detected, and two cases with PCR-confirmed COVID-19 did not develop IgG antibodies. Conclusion: The low rate of seroconversion during the study suggests that it is possible to prevent transmission of SARS-COV-2 in a high-exposure environment. Compliance with adequate infection control guidelines is the likely explanation of our findings.
引用
收藏
页码:169 / 175
页数:7
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