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Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation
被引:67
作者:
Moninuola, O. O.
[1
]
Milligan, W.
[2
]
Lochhead, P.
[3
]
Khalili, H.
[3
,4
,5
]
机构:
[1] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02115 USA
[2] Univ Aberdeen, Aberdeen, Scotland
[3] Massachusetts Gen Hosp, Dept Med, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA
[5] Harvard Med Sch, Boston, MA USA
关键词:
INFLAMMATORY-BOWEL-DISEASE;
SELECTIVE CYCLOOXYGENASE-2 INHIBITORS;
CLINICAL RELAPSE;
ASPIRIN;
ROFECOXIB;
INGESTION;
SAFETY;
COHORT;
FLARES;
D O I:
10.1111/apt.14606
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Background: Unlike acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) have generally been thought to be associated with increased risk of IBD exacerbation. Aim: To carry out a systematic review and meta-analysis of previous studies examining the association between acetaminophen and NSAIDs including cyclooxygenase (COX-2) inhibitors use, and risk of Crohn's disease (CD) and ulcerative colitis (UC) exacerbation. Methods: We identified published manuscripts and abstracts through 1 March 2017 by systematic search of Medline, Embase, Cochrane and other trial registries. Quality assessment was done using Newcastle-Ottawa scale and random-effect meta-analysis using pooled relative risks (RRs) and 95% CIs were calculated. Results: Eighteen publications between years 1983 and 2016 were identified. For the meta-analysis, pooled RRs of disease exacerbation with NSAIDs use were (1.42, 95% CI, 0.65-3.09), I-2=60.3% for CD, and (1.52, 95% CI, 0.87-2.63), I-2=56.1% for UC. The corresponding values for acetaminophen use were (1.40, 95% CI, 0.96-2.04), I-2=45.6% for UC, and (1.56, 95% CI, 1.22-1.99), I-2=0.0% for IBD. Sensitivity analyses limited to studies with low risk of bias showed a significantly increased risk of CD exacerbation (1.53, 95% CI, 1.08-2.16) but not UC (0.94, 95% CI, 0.36-2.42) with NSAIDs use. Conclusions: Contrary to generally accepted belief, we did not find a consistent association between NSAIDs use and risk of CD and UC exacerbation. There was also no consistent evidence for association with acetaminophen although further studies are needed.
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页码:1428 / 1439
页数:12
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