Species differences in drug plasma protein binding

被引：48

作者：

Colclough, Nicola ^{[1
]}

Ruston, Linette ^{[1
]}

Wood, J. Matthew ^{[1
]}

MacFaul, Philip A. ^{[1
]}

机构：

[1] AstraZeneca, Mereside, Macclesfield SK10 4TG, Cheshire, England

来源：

MEDCHEMCOMM | 2014年 / 5卷 / 07期

关键词：

SERUM ALBUMINS; PHARMACOKINETICS; RAT; DISCOVERY; HUMANS; SITES; MOUSE; DOG;

D O I：

10.1039/c4md00148f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Comparison of the human plasma protein binding data for a variety of drug discovery compounds indicates that compounds tend to be slightly more bound to human plasma proteins, than compared to plasma proteins from rats, dogs or mice. However, the majority of measurements from the pre-clinical species fall within 5-fold of the human plasma value, although there are some compounds that do show significantly different interspecies plasma protein binding.

引用

页码：963 / 967

页数：5

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