Gold Nanoparticles in Cancer Therapy: Efficacy, Biodistribution, and Toxicity

被引：27
作者：
Zhao, Jun [1 ]
Lee, Patrick [2 ,3 ]
Wallace, Michael J. [2 ]
Melancon, Marites P. [2 ,4 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Canc Syst Imaging, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Intervent Radiol, Houston, TX 77030 USA
[3] SUNY Upstate Med Univ, Coll Med, Syracuse, NY 13210 USA
[4] Univ Texas Hlth Sci Ctr Houston, Grad Sch Biomed Sci, Houston, TX 77225 USA
来源：
CURRENT PHARMACEUTICAL DESIGN | 2015年 / 21卷 / 29期
关键词：
Gold nanoparticles; biodistribution; toxicity; laser ablation; drug delivery; hyperthermia; IN-VIVO; STEM-CELLS; PHOTOTHERMAL ABLATION; LASER-ABLATION; DISACCHARIDE MOIETY; THERMAL ABLATION; CELLULAR UPTAKE; PROTEIN CORONA; ROS GENERATION; PARTICLE-SIZE;
D O I：
10.2174/1381612821666150901103032
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gold -based nanoparticles are utilized for cancer therapeutics as a system for drug delivery, or as a mediator for thermal therapy, whether ablation or hyperthermia. This review discusses how the design of the physicochemical properties of the different types of gold-based nanoparticles affects their treatment efficacy. The basic principles and mechanism at which it mediates heating and delivers drugs efficiently in vivo is also summarized. We will also review the in vivo preclinical data on the biodistribution, intratumoral distribution, cell internalization, and its associated toxicity. Lastly, an updated list of the clinical trials based on nanoparticles and future perspectives are provided.
引用
收藏
页码：4240 / 4251
页数：12
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