Phytoestrogens β-Sitosterol and Genistein Have Limited Effects on Reproductive Endpoints in a Female Fish, Betta splendens

被引：11
作者：
Brown, A. C. [1 ,2 ,3 ]
Stevenson, L. M. [1 ,4 ]
Leonard, H. M. [1 ]
Nieves-Puigdoller, K. [1 ]
Clotfelter, E. D. [1 ]
机构：
[1] Amherst Coll, Dept Biol, Amherst, MA 01002 USA
[2] Univ Massachusetts, Grad Program Organism & Evolutionary Biol, Amherst, MA 01003 USA
[3] Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21218 USA
[4] Univ Calif Santa Barbara, Doctoral Program Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
基金：
美国国家科学基金会;
关键词：
SIAMESE FIGHTING FISH; OPERCULAR DISPLAYS; MILL EFFLUENT; BEHAVIOR; ENDOCRINE; EXPOSURE; WATER; PULP; 17-BETA-ESTRADIOL; CHOLESTEROL;
D O I：
10.1155/2014/681396
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Phytoestrogens are produced by plants and may cause endocrine disruption in vertebrates. The present study hypothesizes that phytoestrogen exposure of female Siamese fighting fish (Betta splendens) may disrupt endogenous steroid levels, change agonistic behavior expression, and potentially also disrupt oocyte development. However, only the pharmacologic dose of beta-sitosterol had a significant effect on opercular flaring behavior, while we did not find significant effects of beta-sitosterol or genistein on steroids or gonads. These findings are in direct contrast with previous studies on the effects of phytoestrogens in female fish. Results of the current study support previous work showing that the effects of phytoestrogen exposure may be less acute in mature female B. splendens than in other fish.
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