The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders

被引：148

作者：

Faber, Scott ^{[1
]}

Zinn, Gregory M. ^{[2
]}

Kern, John C., II ^{[3
]}

Kingston, H. M. Skip ^{[2
]}

机构：

[1] Childrens Inst, Pittsburgh, PA 15217 USA

[2] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA 15219 USA

[3] Duquesne Univ, Dept Math & Comp Sci, Pittsburgh, PA 15219 USA

来源：

BIOMARKERS | 2009年 / 14卷 / 03期

关键词：

Plasma zinc; serum copper ratio; zinc deficiency; metallothionein system dysfunction; mercury; autistic disorder; pervasive developmental disorder-NOS; Asperger's syndrome; ENVIRONMENTAL MERCURY RELEASE; NEURODEVELOPMENTAL DISORDERS; ENZYME-ACTIVITIES; ZINC-DEFICIENCY; IN-VITRO; METALLOTHIONEIN; METABOLISM; PORPHYRINURIA; EXPRESSION; TOXICITY;

D O I：

10.1080/13547500902783747

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The frequency of zinc deficiency, copper toxicity and low zinc/copper in children with autism spectrum disorders (ASDs) may indicate decrement in metallothionein system functioning. A retrospective review of plasma zinc, serum copper and zinc/copper was performed on data from 230 children with autistic disorder, pervasive developmental disorder-NOS and Asperger's syndrome. The entire cohort's mean zinc level was 77.2 g dl-1, mean copper level was 131.5 g dl-1, and mean Zn/Cu was 0.608, which was below the 0.7 cut-off of the lowest 2.5% of healthy children. The plasma zinc/serum copper ratio may be a biomarker of heavy metal, particularly mercury, toxicity in children with ASDs.

引用

页码：171 / 180

页数：10

共 61 条

[51] Human whole-body copper metabolism [J].